Abstract
Current evidence suggests that the aetiology of congenital gastrointestinal (GI) tract atresia is multifactorial, and not based solely on genetic factors. However, there are no established modifiable risk factors for congenital GI tract atresia. We used data from a Japanese nationwide birth cohort study launched in 2011, and examined whether fish consumption in early pregnancy was associated with congenital GI tract atresia. We analysed data of 89 495 women (mean age at delivery=31·2 years) who delivered singleton live births without chromosomal anomalies. Based on the results of the FFQ, we estimated the daily intake of fish and n-3 PUFA consumption in early pregnancy. We defined a composite outcome (oesophageal atresia, duodenal atresia, jejunoileal atresia and/or anorectal malformation) as congenital GI tract atresia. In this population, median fish intake was 31·9 g/d, and seventy-four cases of congenital GI tract atresia were identified. Fish consumption in early pregnancy was inversely associated with the composite outcome (multivariable-adjusted OR for the high v. low consumption category=0·5, 95 % CI 0·3, 1·0). For all the specific types of atresia, decreased OR were observed in the high consumption category, although not statistically significant. Reduced atresia occurrence was observed even beyond the US Food and Drug Administration's recommended consumption of no more than 340 g/week. Also, n-3 PUFA-rich fish and n-3 PUFA consumptions tended to be inversely associated with atresia. Fish consumption in early pregnancy may be a preventive factor for congenital GI tract atresia.
| Original language | English |
|---|---|
| Journal | British Journal of Nutrition |
| DOIs | |
| Publication status | Accepted/In press - 2018 Jan 1 |
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Keywords
- Anorectal malformation
- Birth cohorts
- Fish consumption
- Intestinal atresia
- Oesophageal atresia
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Fish consumption in early pregnancy and congenital gastrointestinal tract atresia in the Japan Environment and Children's Study. / Michikawa, Takehiro; Yamazaki, Shin; Ono, Masaji; Kuroda, Tatsuo; Nakayama, Shoji F.; Suda, Eiko; Isobe, Tomohiko; Iwai-Shimada, Miyuki; Kobayashi, Yayoi; Tamura, Kenji; Yonemoto, Junzo; Kawamoto, Toshihiro; Nitta, Hiroshi.
In: British Journal of Nutrition, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fish consumption in early pregnancy and congenital gastrointestinal tract atresia in the Japan Environment and Children's Study
AU - Michikawa, Takehiro
AU - Yamazaki, Shin
AU - Ono, Masaji
AU - Kuroda, Tatsuo
AU - Nakayama, Shoji F.
AU - Suda, Eiko
AU - Isobe, Tomohiko
AU - Iwai-Shimada, Miyuki
AU - Kobayashi, Yayoi
AU - Tamura, Kenji
AU - Yonemoto, Junzo
AU - Kawamoto, Toshihiro
AU - Nitta, Hiroshi
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Current evidence suggests that the aetiology of congenital gastrointestinal (GI) tract atresia is multifactorial, and not based solely on genetic factors. However, there are no established modifiable risk factors for congenital GI tract atresia. We used data from a Japanese nationwide birth cohort study launched in 2011, and examined whether fish consumption in early pregnancy was associated with congenital GI tract atresia. We analysed data of 89 495 women (mean age at delivery=31·2 years) who delivered singleton live births without chromosomal anomalies. Based on the results of the FFQ, we estimated the daily intake of fish and n-3 PUFA consumption in early pregnancy. We defined a composite outcome (oesophageal atresia, duodenal atresia, jejunoileal atresia and/or anorectal malformation) as congenital GI tract atresia. In this population, median fish intake was 31·9 g/d, and seventy-four cases of congenital GI tract atresia were identified. Fish consumption in early pregnancy was inversely associated with the composite outcome (multivariable-adjusted OR for the high v. low consumption category=0·5, 95 % CI 0·3, 1·0). For all the specific types of atresia, decreased OR were observed in the high consumption category, although not statistically significant. Reduced atresia occurrence was observed even beyond the US Food and Drug Administration's recommended consumption of no more than 340 g/week. Also, n-3 PUFA-rich fish and n-3 PUFA consumptions tended to be inversely associated with atresia. Fish consumption in early pregnancy may be a preventive factor for congenital GI tract atresia.
AB - Current evidence suggests that the aetiology of congenital gastrointestinal (GI) tract atresia is multifactorial, and not based solely on genetic factors. However, there are no established modifiable risk factors for congenital GI tract atresia. We used data from a Japanese nationwide birth cohort study launched in 2011, and examined whether fish consumption in early pregnancy was associated with congenital GI tract atresia. We analysed data of 89 495 women (mean age at delivery=31·2 years) who delivered singleton live births without chromosomal anomalies. Based on the results of the FFQ, we estimated the daily intake of fish and n-3 PUFA consumption in early pregnancy. We defined a composite outcome (oesophageal atresia, duodenal atresia, jejunoileal atresia and/or anorectal malformation) as congenital GI tract atresia. In this population, median fish intake was 31·9 g/d, and seventy-four cases of congenital GI tract atresia were identified. Fish consumption in early pregnancy was inversely associated with the composite outcome (multivariable-adjusted OR for the high v. low consumption category=0·5, 95 % CI 0·3, 1·0). For all the specific types of atresia, decreased OR were observed in the high consumption category, although not statistically significant. Reduced atresia occurrence was observed even beyond the US Food and Drug Administration's recommended consumption of no more than 340 g/week. Also, n-3 PUFA-rich fish and n-3 PUFA consumptions tended to be inversely associated with atresia. Fish consumption in early pregnancy may be a preventive factor for congenital GI tract atresia.
KW - Anorectal malformation
KW - Birth cohorts
KW - Fish consumption
KW - Intestinal atresia
KW - Oesophageal atresia
UR - http://www.scopus.com/inward/record.url?scp=85055705378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055705378&partnerID=8YFLogxK
U2 - 10.1017/S0007114518002842
DO - 10.1017/S0007114518002842
M3 - Article
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
ER -