Five new C-methyl flavonoids, the potent aldose reductase inhibitors from Matteuccia orientalis TREV.

P. Basnet, S. Kadota, Kouji Hase, T. Namba

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Five new compounds, matteuorien, matteuorienin, and matteuorienate A (7), B (8), and C (9) were isolated together with five known compounds from the MeOH extract of the rhizome of Matteuccia orientalis TREV. The structures of these compounds were determined by the use of spectroscopic methods including two dimensional (2D)-NMR experiments and chemical methods, except for the configuration at the C-3''' of matteuorienate A (7), B (8), and C (9). Among them, matteuorienate A, B, and C showed very strong aldose reductase inhibitory activity. A structure-activity relationship study showed that a carboxyl group played an important part in aldose reductase inhibitory activity in these three compounds.

Original languageEnglish
Pages (from-to)1558-1564
Number of pages7
JournalChemical and Pharmaceutical Bulletin
Volume43
Issue number9
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

Aldehyde Reductase
Flavonoids
Rhizome
Structure-Activity Relationship
Nuclear magnetic resonance
matteuorienate A
Experiments

Keywords

  • aldose reductase inhibitors
  • C-methyl flavonoid
  • Matteuccia orientalis
  • matteuorienate A
  • matteuorienate B
  • matteuorienate C

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Five new C-methyl flavonoids, the potent aldose reductase inhibitors from Matteuccia orientalis TREV. / Basnet, P.; Kadota, S.; Hase, Kouji; Namba, T.

In: Chemical and Pharmaceutical Bulletin, Vol. 43, No. 9, 1995, p. 1558-1564.

Research output: Contribution to journalArticle

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