Five New C-Methyl Flavonoids, the Potent Aldose Reductase Inhibitors from Matteuccia orientalis trev.

Purusotam Basnet, Shigetoshi Kadota, Koji Hase, Tsuneo Namba

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Five new compounds, matteuorien, matteuorienin, and matteuorienate A (7), B (8), and C (9) were isolated together with five known compounds from the MeOH extract of the rhizome of Matteuccia orientalis trev. The structures of these compounds were determined by the use of spectroscopic methods including two dimensional (2D)-NMR experiments and chemical methods, except for the configuration at the C-3’” of matteuorienate A (7), B (8), and C (9). Among them, matteuorienate A, B, and C showed very strong aldose reductase inhibitory activity. A structure-activity relationship study showed that a carboxyl group played an important part in aldose reductase inhibitory activity in these three compounds.

Original languageEnglish
Pages (from-to)1558-1564
Number of pages7
JournalChemical and Pharmaceutical Bulletin
Volume43
Issue number9
DOIs
Publication statusPublished - 1995 Jan 1
Externally publishedYes

Keywords

  • C-methyl flavonoid
  • Matteuccia orientalis
  • aldose reductase inhibitors
  • matteuorienate A
  • matteuorienate B
  • matteuorienate C

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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