Five types of inflammatory arthritis following total knee arthroplasty

Yasuo Niki, Hideo Matsumoto, Toshiro Otani, Taisuke Tomatsu, Yoshiaki Toyama

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Joint effusion after total knee arthroplasty (TKA) is considered as a manifestation of certain inflammatory reactions within prosthetic joints. This study investigated causes of joint effusion following TKA and analyzed phenotypic characteristics of synovial fluid leukocytes for each cause. Forty-six TKAs for rheumatoid arthritis (RA) and 49 TKAs for osteoarthritis (OA) displaying joint effusion were investigated. Causes of joint effusion were clinically identified and frequencies of each cause were compared between RA and OA. Synovial fluid cell phenotypes were analyzed using a fluorescence-activated cell sorter. Clinical diagnoses for joint effusion were classified into five different groups: deep infection (DI); increased activity of RA (IRA); particle-induced synovitis (PS); metal sensitivity (MS); and nonspecific synovitis (NS). The most frequent cause of post-TKA effusion was IRA in RA, and NS in OA. Biomaterial-related arthritis such as PS and MS were more frequent with OA than with RA. Analysis of synovial fluid cell phenotypes revealed that the characteristic cells for each diagnosis were CD16+CD14 - neutrophils in IRA and DI, CD14+ macrophages in PS, and CD3+CD45RO+ T cells in MS. Post-TKA joint effusion is clinically caused by five different types of arthritis. Phenotypic characteristics of synovial fluid leukocytes reflect joint pathology and contribute to diagnosis and exclusion of biomaterial-related arthritis.

Original languageEnglish
Pages (from-to)1005-1010
Number of pages6
JournalJournal of Biomedical Materials Research - Part A
Volume81
Issue number4
DOIs
Publication statusPublished - 2007 Jun 15

Fingerprint

Arthroplasty
Fluids
Metals
Biocompatible Materials
Biomaterials
T-cells
Macrophages
Pathology
Prosthetics
Fluorescence

Keywords

  • Biomaterial-related arthritis
  • Osteoarthritis
  • Rheumatoid arthritis
  • Synovial fluid leukocyte
  • Total knee arthroplasty

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Five types of inflammatory arthritis following total knee arthroplasty. / Niki, Yasuo; Matsumoto, Hideo; Otani, Toshiro; Tomatsu, Taisuke; Toyama, Yoshiaki.

In: Journal of Biomedical Materials Research - Part A, Vol. 81, No. 4, 15.06.2007, p. 1005-1010.

Research output: Contribution to journalArticle

Niki, Yasuo ; Matsumoto, Hideo ; Otani, Toshiro ; Tomatsu, Taisuke ; Toyama, Yoshiaki. / Five types of inflammatory arthritis following total knee arthroplasty. In: Journal of Biomedical Materials Research - Part A. 2007 ; Vol. 81, No. 4. pp. 1005-1010.
@article{a6773d236bb9494d8b19fafd5f3f623f,
title = "Five types of inflammatory arthritis following total knee arthroplasty",
abstract = "Joint effusion after total knee arthroplasty (TKA) is considered as a manifestation of certain inflammatory reactions within prosthetic joints. This study investigated causes of joint effusion following TKA and analyzed phenotypic characteristics of synovial fluid leukocytes for each cause. Forty-six TKAs for rheumatoid arthritis (RA) and 49 TKAs for osteoarthritis (OA) displaying joint effusion were investigated. Causes of joint effusion were clinically identified and frequencies of each cause were compared between RA and OA. Synovial fluid cell phenotypes were analyzed using a fluorescence-activated cell sorter. Clinical diagnoses for joint effusion were classified into five different groups: deep infection (DI); increased activity of RA (IRA); particle-induced synovitis (PS); metal sensitivity (MS); and nonspecific synovitis (NS). The most frequent cause of post-TKA effusion was IRA in RA, and NS in OA. Biomaterial-related arthritis such as PS and MS were more frequent with OA than with RA. Analysis of synovial fluid cell phenotypes revealed that the characteristic cells for each diagnosis were CD16+CD14 - neutrophils in IRA and DI, CD14+ macrophages in PS, and CD3+CD45RO+ T cells in MS. Post-TKA joint effusion is clinically caused by five different types of arthritis. Phenotypic characteristics of synovial fluid leukocytes reflect joint pathology and contribute to diagnosis and exclusion of biomaterial-related arthritis.",
keywords = "Biomaterial-related arthritis, Osteoarthritis, Rheumatoid arthritis, Synovial fluid leukocyte, Total knee arthroplasty",
author = "Yasuo Niki and Hideo Matsumoto and Toshiro Otani and Taisuke Tomatsu and Yoshiaki Toyama",
year = "2007",
month = "6",
day = "15",
doi = "10.1002/jbm.a.31152",
language = "English",
volume = "81",
pages = "1005--1010",
journal = "Journal of Biomedical Materials Research",
issn = "1549-3296",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Five types of inflammatory arthritis following total knee arthroplasty

AU - Niki, Yasuo

AU - Matsumoto, Hideo

AU - Otani, Toshiro

AU - Tomatsu, Taisuke

AU - Toyama, Yoshiaki

PY - 2007/6/15

Y1 - 2007/6/15

N2 - Joint effusion after total knee arthroplasty (TKA) is considered as a manifestation of certain inflammatory reactions within prosthetic joints. This study investigated causes of joint effusion following TKA and analyzed phenotypic characteristics of synovial fluid leukocytes for each cause. Forty-six TKAs for rheumatoid arthritis (RA) and 49 TKAs for osteoarthritis (OA) displaying joint effusion were investigated. Causes of joint effusion were clinically identified and frequencies of each cause were compared between RA and OA. Synovial fluid cell phenotypes were analyzed using a fluorescence-activated cell sorter. Clinical diagnoses for joint effusion were classified into five different groups: deep infection (DI); increased activity of RA (IRA); particle-induced synovitis (PS); metal sensitivity (MS); and nonspecific synovitis (NS). The most frequent cause of post-TKA effusion was IRA in RA, and NS in OA. Biomaterial-related arthritis such as PS and MS were more frequent with OA than with RA. Analysis of synovial fluid cell phenotypes revealed that the characteristic cells for each diagnosis were CD16+CD14 - neutrophils in IRA and DI, CD14+ macrophages in PS, and CD3+CD45RO+ T cells in MS. Post-TKA joint effusion is clinically caused by five different types of arthritis. Phenotypic characteristics of synovial fluid leukocytes reflect joint pathology and contribute to diagnosis and exclusion of biomaterial-related arthritis.

AB - Joint effusion after total knee arthroplasty (TKA) is considered as a manifestation of certain inflammatory reactions within prosthetic joints. This study investigated causes of joint effusion following TKA and analyzed phenotypic characteristics of synovial fluid leukocytes for each cause. Forty-six TKAs for rheumatoid arthritis (RA) and 49 TKAs for osteoarthritis (OA) displaying joint effusion were investigated. Causes of joint effusion were clinically identified and frequencies of each cause were compared between RA and OA. Synovial fluid cell phenotypes were analyzed using a fluorescence-activated cell sorter. Clinical diagnoses for joint effusion were classified into five different groups: deep infection (DI); increased activity of RA (IRA); particle-induced synovitis (PS); metal sensitivity (MS); and nonspecific synovitis (NS). The most frequent cause of post-TKA effusion was IRA in RA, and NS in OA. Biomaterial-related arthritis such as PS and MS were more frequent with OA than with RA. Analysis of synovial fluid cell phenotypes revealed that the characteristic cells for each diagnosis were CD16+CD14 - neutrophils in IRA and DI, CD14+ macrophages in PS, and CD3+CD45RO+ T cells in MS. Post-TKA joint effusion is clinically caused by five different types of arthritis. Phenotypic characteristics of synovial fluid leukocytes reflect joint pathology and contribute to diagnosis and exclusion of biomaterial-related arthritis.

KW - Biomaterial-related arthritis

KW - Osteoarthritis

KW - Rheumatoid arthritis

KW - Synovial fluid leukocyte

KW - Total knee arthroplasty

UR - http://www.scopus.com/inward/record.url?scp=34249717788&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249717788&partnerID=8YFLogxK

U2 - 10.1002/jbm.a.31152

DO - 10.1002/jbm.a.31152

M3 - Article

C2 - 17265437

AN - SCOPUS:34249717788

VL - 81

SP - 1005

EP - 1010

JO - Journal of Biomedical Materials Research

JF - Journal of Biomedical Materials Research

SN - 1549-3296

IS - 4

ER -