Five-year follow-up of a woman with pregnancy and lactation-associated osteoporosis and vertebral fractures

Jun Iwamoto, Yoshihiro Sato, Mitsuyoshi Uzawa, Hideo Matsumoto

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We report the 5-year follow-up of a young woman who developed vertebral fractures after pregnancy and lactation and was treated with active vitamin D hormone. A 32-year-old Japanese woman consulted us because of acute lower back pain caused by L2 and L5 vertebral fractures after pregnancy and lactation. Following cessation of breast-feeding, analgesia, bed rest, and wearing of a hard brace, her lower back pain disappeared within 2 months. After 5 years of treatment with alfacalcidol 1 μg daily, the lumbar spine (L1, L3, L4) bone mineral density increased by 21.4% following vigorous reductions in bone turnover markers. No osteoporotic fractures occurred, and the vertebral fractures healed. The patient experienced no side effects, including hypercalcemia. Thus, the present case report shows long-term changes in bone turnover markers and lumbar spine bone mineral density, as well as long-term safety of alfacalcidol treatment in a young woman with pregnancy and lactation-associated osteoporosis and vertebral fractures.

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalTherapeutics and Clinical Risk Management
Volume8
DOIs
Publication statusPublished - 2012 Dec 1

Keywords

  • Alfacalcidol
  • Bone mineral density
  • Osteoporosis
  • Pregnancy
  • Vertebral fracture
  • Young woman

ASJC Scopus subject areas

  • Safety Research
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)
  • Chemical Health and Safety

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