Five-Year Outcome of LASIK for Myopia

Naoko Kato, Ikuko Toda, Yoshiko Hori-Komai, Chikako Sakai, Kazuo Tsubota

Research output: Contribution to journalArticle

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Abstract

Purpose: To investigate the efficacy and safety of LASIK over a 5-year postoperative period. Design: Observational case series. Participants: We examined 779 eyes in 402 patients with myopia or myopic astigmatism who underwent LASIK to correct their refractive errors and received regular postoperative assessments for 5 years. Methods: Postoperative examinations were performed 1 day; 1 week; 1, 3, and 6 months; and 1, 2, 3, 4, and 5 years after LASIK surgery. Main Outcome Measures: We evaluated changes in uncorrected visual acuity (UCVA) (logarithm of the minimum angle of resolution [logMAR]), manifest refraction, best-corrected visual acuity (BCVA) (logMAR), intraocular pressure, corneal thickness, corneal endothelial cell counts, and complications. Results: Preoperative UCVA of 1.27 improved to -0.03 at 1 day after surgery and -0.08 at 1 month and revealed minimal but significant decreases thereafter. Postoperative manifest refraction was also improved by surgery, showing minimal but significant regression after 1 year. Final BCVA loss was seen in 10 eyes of 7 patients; in 7 cases, there were obvious reasons such as the progression of cataracts in 3 eyes, epithelial disintegrity due to dry eye in 2 eyes, irregular astigmatism due to flap striae in 1 eye, and age-related macular dystrophy in 1 eye. Intraocular pressure and corneal thickness decreased by 4.0 mmHg and 76.9 μm, respectively, due to surgery, but remained stable throughout the follow-up period. Corneal endothelial cell counts (2689.0±232.9 cells/mm2 before surgery) showed a statistically significant decrease at 5 years after surgery (2658.0±183.1 cells/mm2; 1.2% loss for 5 years), likely within the range due to physiological age-related loss. No serious, vision-threatening, irreversible complication such as keratectasia or progressive endothelial cell loss was observed. Conclusion: LASIK surgery is an effective and safe procedure for correcting myopia/myopic astigmatism as long as inclusion and exclusion criteria are strictly respected. However, minimal regression occurred during the 5-year investigative period.

Original languageEnglish
JournalOphthalmology
Volume115
Issue number5
DOIs
Publication statusPublished - 2008 May

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Laser In Situ Keratomileusis
Myopia
Visual Acuity
Astigmatism
Endothelial Cells
Intraocular Pressure
Cell Count
Refractive Errors
Macular Degeneration
Ambulatory Surgical Procedures
Postoperative Period
Cataract
Outcome Assessment (Health Care)
Safety

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Five-Year Outcome of LASIK for Myopia. / Kato, Naoko; Toda, Ikuko; Hori-Komai, Yoshiko; Sakai, Chikako; Tsubota, Kazuo.

In: Ophthalmology, Vol. 115, No. 5, 05.2008.

Research output: Contribution to journalArticle

Kato, Naoko ; Toda, Ikuko ; Hori-Komai, Yoshiko ; Sakai, Chikako ; Tsubota, Kazuo. / Five-Year Outcome of LASIK for Myopia. In: Ophthalmology. 2008 ; Vol. 115, No. 5.
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