Flavonoid Constituents of Dracocephalum kotschyi Growing in Iran and Their Trypanocidal Activity

Ahmad Reza Gohari, Soodabeh Saeidnia, Kenji Matsuo, Nahoko Uchiyama, Toru Yagura, Michiho Ito, Fumiyuki Kiuchi, Gisho Honda

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Nine flavonoids, calycopterin, xanthomicrol, isokaempferide, luteolin, apigenin, luteolin 7-O-β-D-glucopyranoside, luteolin 3′-O-β -D-glucuronide, apigenin 4′-O-β-D-glucopyranoside, and acacetin 7-O-β-D-glucopyranoside, together with a phenolic, rosmarinic acid, were isolated from the EtOAc and MeOH extracts of Dracocephalum kotschyi Boiss. Isokaempferide and apigenin showed lethality against epimastigotes of Trypanosoma cruzi, the etiological agent of Chagas disease.

Original languageEnglish
Pages (from-to)250-252
Number of pages3
JournalNatural Medicines
Volume57
Issue number6
Publication statusPublished - 2003 Dec 1
Externally publishedYes

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Keywords

  • Dracocephalum kotschyi
  • Flavonoid
  • Labiatae
  • Trypanocidal activity
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Gohari, A. R., Saeidnia, S., Matsuo, K., Uchiyama, N., Yagura, T., Ito, M., Kiuchi, F., & Honda, G. (2003). Flavonoid Constituents of Dracocephalum kotschyi Growing in Iran and Their Trypanocidal Activity. Natural Medicines, 57(6), 250-252.