Flow-cytometric analysis of immune cell populations in human decidua from various types of first-trimester pregnancy

Tetsuo Maruyama, Tsunehisa Makino, Toshitaka Sugi, Hidehiko Matsubayashi, Nobuaki Ozawa, Shiro Nozawa

Research output: Contribution to journalArticle

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Abstract

We undertook an investigation in which flow cytometry was used to characterize immune cell populations in the decidua of first-trimester normal pregnancies, spontaneous abortions, and ectopic pregnancies in comparison to the nonpregnant endometrium to demonstrate how the proportions of immunocompetent cell populations at the fetomaternal interface are influenced by the presence and state of a fetoplacental allograft. No significant differences were found in the decidua of the different types of first-trimester pregnancy in the proportions of the CD45+, CD14+, CD3+, CD4+, CD8+, CD19+, CD3-/Cd+ and/or CD56+, CD3+/ CD16+ and/or CD56+, CD4+/Leu-8+, CD4+/ Leu-8-, CD8+/CD11b+, CD8+/CD11b-, and CD3+/HLA-DR- decidual leukocyte subsets. However, the percentage of decidual CD3+/HLA-DR+ cells, which are characteristic of activated T cells, was significantly higher in spontaneous abortions than in normal pregnancies (p < 0.05). This suggests that the accumulation of decidual leukocytes may be regulated mainly by hormones and/or cytokines rather than by the presence and stage of an intrauterine conceptus and that on/off-switching of activation of decidual T cells may be associated with successful maintenance of the implanted embryo.

Original languageEnglish
Pages (from-to)212-218
Number of pages7
JournalHuman Immunology
Volume34
Issue number3
DOIs
Publication statusPublished - 1992

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Decidua
First Pregnancy Trimester
HLA-DR Antigens
Spontaneous Abortion
Leukocytes
Population
T-Lymphocytes
Ectopic Pregnancy
Endometrium
Allografts
Flow Cytometry
Embryonic Structures
Maintenance
Hormones
Cytokines
Pregnancy

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Flow-cytometric analysis of immune cell populations in human decidua from various types of first-trimester pregnancy. / Maruyama, Tetsuo; Makino, Tsunehisa; Sugi, Toshitaka; Matsubayashi, Hidehiko; Ozawa, Nobuaki; Nozawa, Shiro.

In: Human Immunology, Vol. 34, No. 3, 1992, p. 212-218.

Research output: Contribution to journalArticle

Maruyama, Tetsuo ; Makino, Tsunehisa ; Sugi, Toshitaka ; Matsubayashi, Hidehiko ; Ozawa, Nobuaki ; Nozawa, Shiro. / Flow-cytometric analysis of immune cell populations in human decidua from various types of first-trimester pregnancy. In: Human Immunology. 1992 ; Vol. 34, No. 3. pp. 212-218.
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