Fludarabine, cyclophosphamide, anti-thymocyteglobulin, and low-dose total body irradiation conditioning enables 1-HLA-locus-mismatched hematopoietic stem cell transplantation for very severe aplastic anemia without affecting ovarian function

Shinya Okuda, Kiriko Terasako, Kumi Oshima, Miki Sato, Hideki Nakasone, Shinichi Kako, Rie Yamazaki, Yukie Tanaka, Aki Tanihara, Takakazu Higuchi, Junji Nishida, Yoshinobu Kanda

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Allogeneic hematopoietic stem cell transplantation for severe aplastic anemia from an alternative donor is associated with higher risks of graft rejection and severe graft-versus-host disease. We developed a conditioning regimen consisting of rabbit anti-thymocyte globulin, fludarabine, cyclophosphamide, and low-dose total body irradiation. Two adult female patients with transfusion-dependent very severe aplastic anemia underwent 1-locus mismatched transplantation using this regimen. Both patients achieved stable engraftment and the clinical course thereafter was uneventful with persistently normal ovarian function. This novel conditioning regimen may be suitable for alternative donor transplantation for severe aplastic anemia, especially in young female patients.

Original languageEnglish
Pages (from-to)167-169
Number of pages3
JournalAmerican Journal of Hematology
Volume84
Issue number3
DOIs
Publication statusPublished - 2009 Mar 1
Externally publishedYes

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Aplastic Anemia
Whole-Body Irradiation
Hematopoietic Stem Cell Transplantation
Cyclophosphamide
Transplantation
Tissue Donors
Antilymphocyte Serum
Graft Rejection
Graft vs Host Disease
Rabbits
fludarabine

ASJC Scopus subject areas

  • Hematology

Cite this

Fludarabine, cyclophosphamide, anti-thymocyteglobulin, and low-dose total body irradiation conditioning enables 1-HLA-locus-mismatched hematopoietic stem cell transplantation for very severe aplastic anemia without affecting ovarian function. / Okuda, Shinya; Terasako, Kiriko; Oshima, Kumi; Sato, Miki; Nakasone, Hideki; Kako, Shinichi; Yamazaki, Rie; Tanaka, Yukie; Tanihara, Aki; Higuchi, Takakazu; Nishida, Junji; Kanda, Yoshinobu.

In: American Journal of Hematology, Vol. 84, No. 3, 01.03.2009, p. 167-169.

Research output: Contribution to journalArticle

Okuda, Shinya ; Terasako, Kiriko ; Oshima, Kumi ; Sato, Miki ; Nakasone, Hideki ; Kako, Shinichi ; Yamazaki, Rie ; Tanaka, Yukie ; Tanihara, Aki ; Higuchi, Takakazu ; Nishida, Junji ; Kanda, Yoshinobu. / Fludarabine, cyclophosphamide, anti-thymocyteglobulin, and low-dose total body irradiation conditioning enables 1-HLA-locus-mismatched hematopoietic stem cell transplantation for very severe aplastic anemia without affecting ovarian function. In: American Journal of Hematology. 2009 ; Vol. 84, No. 3. pp. 167-169.
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