Fluorine-incorporated amorphous carbon coating inhibits adhesion of blood cells to biomaterials

Ayumi Horikawa, Shunto Maegawa, Terumitsu Hasebe, Tomohiro Matsumoto, Minoru Tanaka, Koki Takahashi, Tetsuya Suzuki

Research output: Contribution to journalArticle

Abstract

When the surfaces of biomaterials come into contact with human blood, the contact can induce adhesion and activation of platelets and leukocytes following protein adhesion, and these complex reactions cause responses in the body including biomaterial-associated thrombosis and inflammation. Fluorine-incorporated amorphous carbon (a-C:H:F) is widely known as an antithrombogenic thin film and is regarded as a promising coating that can solve the problem of blood-contacting medical devices. However, the anti-inflammatory properties of a-C:H:F have not yet been elucidated. Polymorphonuclear neutrophil leukocytes (neutrophils) play important roles in thrombosis and inflammation, and platelets that adhere to and become activated on biomaterial, which are also key factors of thrombus formation, promote adhesion of neutrophils in an inflammatory process. In this study, to evaluate the antithrombogenic and anti-inflammatory properties of a-C:H:F coating, we analyzed the platelets that had adhered to and become activated on, as well as neutrophils that had adhered to, a-C:H:F-coated SUS316L, which is a conventional material used for medical devices. The a-C:H:F-coated SUS316L suppressed platelet adhesion and activation and neutrophil adhesion to a greater extent than uncoated SUS316L. These results showed that a-C:H:F coating is a suitable and biocompatible coating for implanted devices because it controls the initial thrombotic and inflammatory reactions of biomaterials.

Original languageEnglish
Pages (from-to)795-803
Number of pages9
JournalSensors and Materials
Volume29
Issue number6
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

blood cells
Fluorine
Amorphous carbon
neutrophils
Biocompatible Materials
leukocytes
Biomaterials
fluorine
Platelets
platelets
adhesion
Blood
Adhesion
Cells
coatings
Coatings
carbon
thrombosis
blood
Anti-Inflammatory Agents

Keywords

  • Amorphous carbon
  • Anti-inflammation
  • Antithrombogenic
  • Biomaterial
  • Fluorine doping

ASJC Scopus subject areas

  • Instrumentation
  • Materials Science(all)

Cite this

Fluorine-incorporated amorphous carbon coating inhibits adhesion of blood cells to biomaterials. / Horikawa, Ayumi; Maegawa, Shunto; Hasebe, Terumitsu; Matsumoto, Tomohiro; Tanaka, Minoru; Takahashi, Koki; Suzuki, Tetsuya.

In: Sensors and Materials, Vol. 29, No. 6, 01.01.2017, p. 795-803.

Research output: Contribution to journalArticle

Horikawa, A, Maegawa, S, Hasebe, T, Matsumoto, T, Tanaka, M, Takahashi, K & Suzuki, T 2017, 'Fluorine-incorporated amorphous carbon coating inhibits adhesion of blood cells to biomaterials', Sensors and Materials, vol. 29, no. 6, pp. 795-803. https://doi.org/10.18494/SAM.2017.1558
Horikawa A, Maegawa S, Hasebe T, Matsumoto T, Tanaka M, Takahashi K et al. Fluorine-incorporated amorphous carbon coating inhibits adhesion of blood cells to biomaterials. Sensors and Materials. 2017 Jan 1;29(6):795-803. https://doi.org/10.18494/SAM.2017.1558
Horikawa, Ayumi ; Maegawa, Shunto ; Hasebe, Terumitsu ; Matsumoto, Tomohiro ; Tanaka, Minoru ; Takahashi, Koki ; Suzuki, Tetsuya. / Fluorine-incorporated amorphous carbon coating inhibits adhesion of blood cells to biomaterials. In: Sensors and Materials. 2017 ; Vol. 29, No. 6. pp. 795-803.
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