Fluoroquinolones reduce carrageenan-induced edema in rats and the involvement of the glucocorticoid receptor system

Hiromi Ogino; Kaori Yamada; Mizuki Yuhara; Saori Tsuchida; Kayoko Maezawa; Junko Kizu; Seiji Hori

doi:10.1007/s10156-009-0675-y

Fluoroquinolones reduce carrageenan-induced edema in rats and the involvement of the glucocorticoid receptor system

Hiromi Ogino, Kaori Yamada, Mizuki Yuhara, Saori Tsuchida, Kayoko Maezawa, Junko Kizu, Seiji Hori

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

We studied the effect of fluoroquinolones (FQs) on carrageenan-induced edema in the rat footpad. Ciprofloxacin, gatifloxacin, sparfloxacin, norfloxacin, and enoxacin (s.c., 100 mg/kg), which have piperazinyl and/or cyclopropyl groups, inhibited carrageenan-induced edema, whereas levofloxacin, tosufloxacin, and pazufloxacin did not. The reduction of edema by ciprofloxacin, sparfloxacin, and enoxacin was abolished by pretreatment with mifepristone, an antagonist of the glucocorticoid receptor. These results suggest that FQs with piperazinyl and/or cyclopropyl groups can modify biological responses through enhancing the glucocorticoid-glucocorticoid receptor system.

Original language	English
Pages (from-to)	113-117
Number of pages	5
Journal	Journal of Infection and Chemotherapy
Volume	15
Issue number	2
DOIs	https://doi.org/10.1007/s10156-009-0675-y
Publication status	Published - 2009 Apr

Keywords

Carrageenan
Fluoroquinolone
Glucocorticoid receptor
Mifepristone
Rat

ASJC Scopus subject areas

Microbiology (medical)
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10156-009-0675-y

Cite this

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title = "Fluoroquinolones reduce carrageenan-induced edema in rats and the involvement of the glucocorticoid receptor system",

abstract = "We studied the effect of fluoroquinolones (FQs) on carrageenan-induced edema in the rat footpad. Ciprofloxacin, gatifloxacin, sparfloxacin, norfloxacin, and enoxacin (s.c., 100 mg/kg), which have piperazinyl and/or cyclopropyl groups, inhibited carrageenan-induced edema, whereas levofloxacin, tosufloxacin, and pazufloxacin did not. The reduction of edema by ciprofloxacin, sparfloxacin, and enoxacin was abolished by pretreatment with mifepristone, an antagonist of the glucocorticoid receptor. These results suggest that FQs with piperazinyl and/or cyclopropyl groups can modify biological responses through enhancing the glucocorticoid-glucocorticoid receptor system.",

keywords = "Carrageenan, Fluoroquinolone, Glucocorticoid receptor, Mifepristone, Rat",

author = "Hiromi Ogino and Kaori Yamada and Mizuki Yuhara and Saori Tsuchida and Kayoko Maezawa and Junko Kizu and Seiji Hori",

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doi = "10.1007/s10156-009-0675-y",

language = "English",

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AU - Ogino, Hiromi

AU - Yamada, Kaori

AU - Yuhara, Mizuki

AU - Tsuchida, Saori

AU - Maezawa, Kayoko

AU - Kizu, Junko

AU - Hori, Seiji

PY - 2009/4

Y1 - 2009/4

N2 - We studied the effect of fluoroquinolones (FQs) on carrageenan-induced edema in the rat footpad. Ciprofloxacin, gatifloxacin, sparfloxacin, norfloxacin, and enoxacin (s.c., 100 mg/kg), which have piperazinyl and/or cyclopropyl groups, inhibited carrageenan-induced edema, whereas levofloxacin, tosufloxacin, and pazufloxacin did not. The reduction of edema by ciprofloxacin, sparfloxacin, and enoxacin was abolished by pretreatment with mifepristone, an antagonist of the glucocorticoid receptor. These results suggest that FQs with piperazinyl and/or cyclopropyl groups can modify biological responses through enhancing the glucocorticoid-glucocorticoid receptor system.

AB - We studied the effect of fluoroquinolones (FQs) on carrageenan-induced edema in the rat footpad. Ciprofloxacin, gatifloxacin, sparfloxacin, norfloxacin, and enoxacin (s.c., 100 mg/kg), which have piperazinyl and/or cyclopropyl groups, inhibited carrageenan-induced edema, whereas levofloxacin, tosufloxacin, and pazufloxacin did not. The reduction of edema by ciprofloxacin, sparfloxacin, and enoxacin was abolished by pretreatment with mifepristone, an antagonist of the glucocorticoid receptor. These results suggest that FQs with piperazinyl and/or cyclopropyl groups can modify biological responses through enhancing the glucocorticoid-glucocorticoid receptor system.

KW - Carrageenan

KW - Fluoroquinolone

KW - Glucocorticoid receptor

KW - Mifepristone

KW - Rat

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ER -

Fluoroquinolones reduce carrageenan-induced edema in rats and the involvement of the glucocorticoid receptor system

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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