Fluoroquinolones reduce carrageenan-induced edema in rats and the involvement of the glucocorticoid receptor system

Hiromi Ogino, Kaori Yamada, Mizuki Yuhara, Saori Tsuchida, Kayoko Maezawa, Junko Kizu, Seiji Hori

Research output: Contribution to journalArticle

Abstract

We studied the effect of fluoroquinolones (FQs) on carrageenan-induced edema in the rat footpad. Ciprofloxacin, gatifloxacin, sparfloxacin, norfloxacin, and enoxacin (s.c., 100 mg/kg), which have piperazinyl and/or cyclopropyl groups, inhibited carrageenan-induced edema, whereas levofloxacin, tosufloxacin, and pazufloxacin did not. The reduction of edema by ciprofloxacin, sparfloxacin, and enoxacin was abolished by pretreatment with mifepristone, an antagonist of the glucocorticoid receptor. These results suggest that FQs with piperazinyl and/or cyclopropyl groups can modify biological responses through enhancing the glucocorticoid-glucocorticoid receptor system.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalJournal of Infection and Chemotherapy
Volume15
Issue number2
DOIs
Publication statusPublished - 2009 Apr

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Keywords

  • Carrageenan
  • Fluoroquinolone
  • Glucocorticoid receptor
  • Mifepristone
  • Rat

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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