Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice

Takayuki Kondo, Misato Funayama, Kayoko Tsukita, Akitsu Hotta, Akimasa Yasuda, Satoshi Nori, Shinjiro Kaneko, Masaya Nakamura, Ryosuke Takahashi, Hideyuki Okano, Shinya Yamanaka, Haruhisa Inoue

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Abstract

Transplantation of glial-rich neural progenitors has been demonstrated to attenuate motor neuron degeneration and disease progression in rodent models of mutant superoxide dismutase 1 (SOD1)-mediated amyotrophic lateral sclerosis (ALS). However, translation of these results into a clinical setting requires a renewable human cell source. Here, we derived glial-rich neural progenitors from human iPSCs and transplanted them into the lumbar spinal cord of ALS mouse models. The transplanted cells differentiated into astrocytes, and the treated mouse group showed prolonged lifespan. Our data suggest a potential therapeutic mechanism via activation of AKT signal. The results demonstrated the efficacy of cell therapy for ALS by the use of human iPSCs as cell source.

Original languageEnglish
Pages (from-to)242-249
Number of pages8
JournalStem cell reports
Volume3
Issue number2
DOIs
Publication statusPublished - 2014 Aug 12

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ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

Cite this

Kondo, T., Funayama, M., Tsukita, K., Hotta, A., Yasuda, A., Nori, S., Kaneko, S., Nakamura, M., Takahashi, R., Okano, H., Yamanaka, S., & Inoue, H. (2014). Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice. Stem cell reports, 3(2), 242-249. https://doi.org/10.1016/j.stemcr.2014.05.017