TY - JOUR
T1 - Folate intake and depressive symptoms in Japanese workers considering SES and job stress factors
T2 - J-HOPE study
AU - Miyaki, Koichi
AU - Song, Yixuan
AU - Htun, Nay C.
AU - Tsutsumi, Akizumi
AU - Hashimoto, Hideki
AU - Kawakami, Norito
AU - Takahashi, Masaya
AU - Shimazu, Akihito
AU - Inoue, Akiomi
AU - Kurioka, Sumiko
AU - Shimbo, Takuro
N1 - Funding Information:
The present cross-sectional study was based on a baseline survey of our occupational cohort study on social class and health, supported by a grant from the Ministry of Education, Culture, Sports, Science and Technology, Japan. Employee of a Japanese major manufacturing company (Headquarter is in Kyoto and the other major 11 offices were spread all over the Japan) were recruited. All workers were invited to participate, and 2266 agreed (aged from 21–65 years; response rate 90.1%). 241 of them are women and account for 10.6%. The protocol and explanation documents of our study were approved by the ethics committee of University of Tokyo School of Medicine, and written informed consent was obtained from each subject.
PY - 2012/4/20
Y1 - 2012/4/20
N2 - Background: Recently socioeconomic status (SES) and job stress index received more attention to affect mental health. Folate intake has been implicated to have negative association with depression. However, few studies were published for the evidence association together with the consideration of SES and job stress factors. The current study is a part of the Japanese study of Health, Occupation and Psychosocial factors related Equity (J-HOPE study) that focused on the association of social stratification and health and our objective was to clarify the association between folate intake and depressive symptoms in Japanese general workers.Methods: Subjects were 2266 workers in a Japanese nationwide company. SES and job stress factors were assessed by self-administered questionnaire. Folate intake was estimated by a validated, brief, self-administered diet history questionnaire. Depressive symptoms were measured by Kessler's K6 questionnaire. " Individuals with depressive symptoms" was defined as K6≧9 (in K6 score of 0-24 scoring system). Multiple logistic regression and linear regression model were used to evaluate the association between folate and depressive symptoms.Results: Several SES factors (proportion of management positions, years of continuous employment, and annual household income) and folate intake were found to be significantly lower in the subjects with depressive symptom (SES factors: p < 0.001; folate intake: P = 0.001). There was an inverse, independent linear association between K6 score and folate intake after adjusting for age, sex, job stress scores (job strains, worksite supports), and SES factors (p = 0.010). The impact of folate intake on the prevalence of depressive symptom by a multiple logistic model was (ORs[95% CI]: 0.813 [0.664-0.994]; P =0.044).Conclusions: Our cross-sectional study suggested an inverse, independent relation of energy-adjusted folate intake with depression score and prevalence of depressive symptoms in Japanese workers, together with the consideration of SES and job stress factors.
AB - Background: Recently socioeconomic status (SES) and job stress index received more attention to affect mental health. Folate intake has been implicated to have negative association with depression. However, few studies were published for the evidence association together with the consideration of SES and job stress factors. The current study is a part of the Japanese study of Health, Occupation and Psychosocial factors related Equity (J-HOPE study) that focused on the association of social stratification and health and our objective was to clarify the association between folate intake and depressive symptoms in Japanese general workers.Methods: Subjects were 2266 workers in a Japanese nationwide company. SES and job stress factors were assessed by self-administered questionnaire. Folate intake was estimated by a validated, brief, self-administered diet history questionnaire. Depressive symptoms were measured by Kessler's K6 questionnaire. " Individuals with depressive symptoms" was defined as K6≧9 (in K6 score of 0-24 scoring system). Multiple logistic regression and linear regression model were used to evaluate the association between folate and depressive symptoms.Results: Several SES factors (proportion of management positions, years of continuous employment, and annual household income) and folate intake were found to be significantly lower in the subjects with depressive symptom (SES factors: p < 0.001; folate intake: P = 0.001). There was an inverse, independent linear association between K6 score and folate intake after adjusting for age, sex, job stress scores (job strains, worksite supports), and SES factors (p = 0.010). The impact of folate intake on the prevalence of depressive symptom by a multiple logistic model was (ORs[95% CI]: 0.813 [0.664-0.994]; P =0.044).Conclusions: Our cross-sectional study suggested an inverse, independent relation of energy-adjusted folate intake with depression score and prevalence of depressive symptoms in Japanese workers, together with the consideration of SES and job stress factors.
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U2 - 10.1186/1471-244X-12-33
DO - 10.1186/1471-244X-12-33
M3 - Article
C2 - 22521003
AN - SCOPUS:84862178365
SN - 1471-244X
VL - 12
JO - BMC Psychiatry
JF - BMC Psychiatry
M1 - 33
ER -
