Folate intake and depressive symptoms in Japanese workers considering SES and job stress factors: J-HOPE study

Koichi Miyaki, Yixuan Song, Nay C. Htun, Akizumi Tsutsumi, Hideki Hashimoto, Norito Kawakami, Masaya Takahashi, Akihito Shimazu, Akiomi Inoue, Sumiko Kurioka, Takuro Shimbo

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Abstract

Background: Recently socioeconomic status (SES) and job stress index received more attention to affect mental health. Folate intake has been implicated to have negative association with depression. However, few studies were published for the evidence association together with the consideration of SES and job stress factors. The current study is a part of the Japanese study of Health, Occupation and Psychosocial factors related Equity (J-HOPE study) that focused on the association of social stratification and health and our objective was to clarify the association between folate intake and depressive symptoms in Japanese general workers.Methods: Subjects were 2266 workers in a Japanese nationwide company. SES and job stress factors were assessed by self-administered questionnaire. Folate intake was estimated by a validated, brief, self-administered diet history questionnaire. Depressive symptoms were measured by Kessler's K6 questionnaire. " Individuals with depressive symptoms" was defined as K6≧9 (in K6 score of 0-24 scoring system). Multiple logistic regression and linear regression model were used to evaluate the association between folate and depressive symptoms.Results: Several SES factors (proportion of management positions, years of continuous employment, and annual household income) and folate intake were found to be significantly lower in the subjects with depressive symptom (SES factors: p < 0.001; folate intake: P = 0.001). There was an inverse, independent linear association between K6 score and folate intake after adjusting for age, sex, job stress scores (job strains, worksite supports), and SES factors (p = 0.010). The impact of folate intake on the prevalence of depressive symptom by a multiple logistic model was (ORs[95% CI]: 0.813 [0.664-0.994]; P =0.044).Conclusions: Our cross-sectional study suggested an inverse, independent relation of energy-adjusted folate intake with depression score and prevalence of depressive symptoms in Japanese workers, together with the consideration of SES and job stress factors.

Original languageEnglish
Article number33
JournalBMC Psychiatry
Volume12
DOIs
Publication statusPublished - 2012 Apr 20
Externally publishedYes

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Folic Acid
Social Class
Depression
Linear Models
Logistic Models
human factor J protein
Health Occupations
Workplace
Mental Health
Cross-Sectional Studies
Psychology
Diet
Health

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Miyaki, K., Song, Y., Htun, N. C., Tsutsumi, A., Hashimoto, H., Kawakami, N., ... Shimbo, T. (2012). Folate intake and depressive symptoms in Japanese workers considering SES and job stress factors: J-HOPE study. BMC Psychiatry, 12, [33]. https://doi.org/10.1186/1471-244X-12-33

Folate intake and depressive symptoms in Japanese workers considering SES and job stress factors : J-HOPE study. / Miyaki, Koichi; Song, Yixuan; Htun, Nay C.; Tsutsumi, Akizumi; Hashimoto, Hideki; Kawakami, Norito; Takahashi, Masaya; Shimazu, Akihito; Inoue, Akiomi; Kurioka, Sumiko; Shimbo, Takuro.

In: BMC Psychiatry, Vol. 12, 33, 20.04.2012.

Research output: Contribution to journalArticle

Miyaki, K, Song, Y, Htun, NC, Tsutsumi, A, Hashimoto, H, Kawakami, N, Takahashi, M, Shimazu, A, Inoue, A, Kurioka, S & Shimbo, T 2012, 'Folate intake and depressive symptoms in Japanese workers considering SES and job stress factors: J-HOPE study', BMC Psychiatry, vol. 12, 33. https://doi.org/10.1186/1471-244X-12-33
Miyaki, Koichi ; Song, Yixuan ; Htun, Nay C. ; Tsutsumi, Akizumi ; Hashimoto, Hideki ; Kawakami, Norito ; Takahashi, Masaya ; Shimazu, Akihito ; Inoue, Akiomi ; Kurioka, Sumiko ; Shimbo, Takuro. / Folate intake and depressive symptoms in Japanese workers considering SES and job stress factors : J-HOPE study. In: BMC Psychiatry. 2012 ; Vol. 12.
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AU - Tsutsumi, Akizumi

AU - Hashimoto, Hideki

AU - Kawakami, Norito

AU - Takahashi, Masaya

AU - Shimazu, Akihito

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AU - Kurioka, Sumiko

AU - Shimbo, Takuro

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