Follicular helper T cells in the pathogenesis of IgG4-related disease

Mitsuhiro Akiyama, Katsuya Suzuki, Hidekata Yasuoka, Yuko Kaneko, Kunihiro Yamaoka, Tsutomu Takeuchi

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

IgG4-related disease (IgG4-RD) is a recently recognized disease entity characterized by high serum IgG4 concentrations and infiltration of IgG4+ plasma cells with hyperplastic ectopic germinal centres at affected sites. Although the underlying immune mechanism of this disease remains unclear, T cells are abundantly present at affected sites and key players in IgG4-RD pathogenesis. The role of T cell subsets has been investigated thoroughly in this disease. Recent advances in this field have clarified the importance of T follicular helper cells. In this review, we describe the role of T follicular helper cells in the disease process of IgG4-RD, in particular, for IgG4 class-switching, plasmablast and plasma cell differentiation, and germinal centre formation.

Original languageEnglish
Article numberkex171
Pages (from-to)236-245
Number of pages10
JournalRheumatology (United Kingdom)
Volume57
Issue number2
DOIs
Publication statusPublished - 2018 Feb 1

Fingerprint

Helper-Inducer T-Lymphocytes
Immunoglobulin G
Germinal Center
Plasma Cells
Immunoglobulin Class Switching
Immune System Diseases
T-Lymphocyte Subsets
Cell Differentiation
T-Lymphocytes
Serum

Keywords

  • Germinal centre
  • IgG4-related disease
  • Interleukin-21
  • Interleukin-4
  • Pathogenesis
  • Plasmablast
  • Somatic hypermutation
  • T follicular helper cell
  • T lymphocyte

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

Cite this

Follicular helper T cells in the pathogenesis of IgG4-related disease. / Akiyama, Mitsuhiro; Suzuki, Katsuya; Yasuoka, Hidekata; Kaneko, Yuko; Yamaoka, Kunihiro; Takeuchi, Tsutomu.

In: Rheumatology (United Kingdom), Vol. 57, No. 2, kex171, 01.02.2018, p. 236-245.

Research output: Contribution to journalReview article

Akiyama, Mitsuhiro ; Suzuki, Katsuya ; Yasuoka, Hidekata ; Kaneko, Yuko ; Yamaoka, Kunihiro ; Takeuchi, Tsutomu. / Follicular helper T cells in the pathogenesis of IgG4-related disease. In: Rheumatology (United Kingdom). 2018 ; Vol. 57, No. 2. pp. 236-245.
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