Follicular lymphoma in two brothers

A. Asahi, Shinichiro Okamoto, H. Matsushita, Yutaka Hattori, N. Takayama, Y. Ikeda

Research output: Contribution to journalArticle

Abstract

Two brothers, whose parents had a history of exposure to atomic bomb radiation, developed non-Hodgkin's lymphoma. The younger brother, a 48-year-old man, was diagnosed as having follicular small-cleaved cell lymphoma in October, 1996. He had extranodal lymphoma involvement of the right kidney, bone marrow and skin, in addition to generalized lymphadenopathy. He was treated with intermittent COP chemotherapy, and good control of the lymphoma was obtained. The elder brother, aged 50 years, was diagnosed as having follicular mixed cell lymphoma in May, 1998. He also had extranodal lymphoma involvement of the right parotid gland and bone marrow, as well as generalized lymphadenopathy. After one course of CHOP chemotherapy, he developed paresis of the lower legs and was found to have a mass at the Th5-6 vertebrae by CT scan. After four courses of CHOP chemotherapy followed by ESHAP chemotherapy and radiotherapy, he achieved complete remission, and has since been well. Follicular lymphoma occurring among siblings is rare. Further cytogenetic and molecular studies may provide a better understanding of its etiology.

Original languageEnglish
Pages (from-to)408-413
Number of pages6
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume42
Issue number5
Publication statusPublished - 2001

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Follicular Lymphoma
Siblings
Drug Therapy
Lymphoma
Bone Marrow
Nuclear Weapons
Parotid Gland
Paresis
Cytogenetics
Non-Hodgkin's Lymphoma
Leg
Spine
Radiotherapy
Parents
Radiation
Kidney
Skin
Lymphadenopathy

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Follicular lymphoma in two brothers. / Asahi, A.; Okamoto, Shinichiro; Matsushita, H.; Hattori, Yutaka; Takayama, N.; Ikeda, Y.

In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 42, No. 5, 2001, p. 408-413.

Research output: Contribution to journalArticle

Asahi, A, Okamoto, S, Matsushita, H, Hattori, Y, Takayama, N & Ikeda, Y 2001, 'Follicular lymphoma in two brothers', [Rinshō ketsueki] The Japanese journal of clinical hematology, vol. 42, no. 5, pp. 408-413.
Asahi, A. ; Okamoto, Shinichiro ; Matsushita, H. ; Hattori, Yutaka ; Takayama, N. ; Ikeda, Y. / Follicular lymphoma in two brothers. In: [Rinshō ketsueki] The Japanese journal of clinical hematology. 2001 ; Vol. 42, No. 5. pp. 408-413.
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AU - Ikeda, Y.

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AB - Two brothers, whose parents had a history of exposure to atomic bomb radiation, developed non-Hodgkin's lymphoma. The younger brother, a 48-year-old man, was diagnosed as having follicular small-cleaved cell lymphoma in October, 1996. He had extranodal lymphoma involvement of the right kidney, bone marrow and skin, in addition to generalized lymphadenopathy. He was treated with intermittent COP chemotherapy, and good control of the lymphoma was obtained. The elder brother, aged 50 years, was diagnosed as having follicular mixed cell lymphoma in May, 1998. He also had extranodal lymphoma involvement of the right parotid gland and bone marrow, as well as generalized lymphadenopathy. After one course of CHOP chemotherapy, he developed paresis of the lower legs and was found to have a mass at the Th5-6 vertebrae by CT scan. After four courses of CHOP chemotherapy followed by ESHAP chemotherapy and radiotherapy, he achieved complete remission, and has since been well. Follicular lymphoma occurring among siblings is rare. Further cytogenetic and molecular studies may provide a better understanding of its etiology.

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