@article{f93713eaaebe42249e6be8e2e0d0e241,
title = "Food restriction reduces cortical bone mass and serum insulin-like growth factor-1 levels and promotes uterine atrophy in mice",
abstract = "Low energy availability in female athletes often causes hypothalamic amenorrhea and osteoporosis, in turn promoting stress fractures. Mechanisms underlying these conditions remain unclear. Here we show that model mice subjected to food restriction (FR) or FR-plus-voluntary running exercise exhibit significantly reduced bone mineral density, cortical bone parameters and uterine weight than do control mice, and that these parameters worsen in the FR-plus-exercise group. Relative to controls, FR and FR-plus-exercise groups showed significantly lower mineral apposition rate and osteoclast number and significantly reduced serum insulin-like growth factor-1 (IGF1) levels. Outcomes were rescued by ED71 or 1.25(OH)2D3 treatment. Thus, we conclude that administration of active vitamin D analogues represents a possible treatment to prevent these conditions.",
keywords = "Cortical bone, Female athletes, Food restriction, IGF-1, Osteoporosis, Vitamin D",
author = "Eri Ito and Yuiko Sato and Tami Kobayashi and Satoshi Nakamura and Yosuke Kaneko and Tomoya Soma and Tatsuaki Matsumoto and Atushi Kimura and Kana Miyamoto and Hideo Matsumoto and Morio Matsumoto and Masaya Nakamura and Kazuki Sato and Takeshi Miyamoto",
note = "Funding Information: We are grateful to the Collaborative Research Resources, Keio University School of Medicine, for technical support. T. Miyamoto was supported by a grant-in-aid for Scientific Research in Japan and a grant from the Japan Agency for Medical Research and Development . Y. Sato and K. Miyamoto were supported by a grant-in-aid for Scientific Research in Japan . Funding Information: We are grateful to the Collaborative Research Resources, Keio University School of Medicine, for technical support. T. Miyamoto was supported by a grant-in-aid for Scientific Research in Japan and a grant from the Japan Agency for Medical Research and Development. Y. Sato and K. Miyamoto were supported by a grant-in-aid for Scientific Research in Japan. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2021",
month = jan,
day = "1",
doi = "10.1016/j.bbrc.2020.11.122",
language = "English",
volume = "534",
pages = "165--171",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
}