Formal total synthesis of altohyrtin C (spongistatin 2). Part 2: Construction of fully elaborated ABCD and EF fragments

Takeshi Terauchi, Taisaku Tanaka, Taro Terauchi, Masataka Morita, Kyoko Kimijima, Ippei Sato, Wataru Shoji, Yasuhiro Nakamura, Tomoharu Tsukada, Takashi Tsunoda, Gouichirou Hayashi, Naoki Kanoh, Masaya Nakata

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Coupling of the C1-C14 (AB) crotylstannane with the C15-C28 (CD) aldehyde followed by stereochemical arrangements gave the C1-C28 (ABCD) fragment of altohyrtin C. The C29-C44 (EF) fragment was also prepared. The syntheses of these two fragments, both of which were identical with those prepared by the Smith group, constitute a formal total synthesis of altohyrtin C.

Original languageEnglish
Pages (from-to)7747-7751
Number of pages5
JournalTetrahedron Letters
Volume44
Issue number42
DOIs
Publication statusPublished - 2003 Oct 13

Keywords

  • Altohyrtins
  • Crotylstannanes
  • Spongistatins
  • Stereoselective synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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