Formal total synthesis of fostriecin via 1,4-asymmetric induction using cobalt-alkyne complex

Yujiro Hayashi, Hirofumi Yamaguchi, Maya Toyoshima, Kotaro Okado, Takumi Toyo, Mitsuru Shoji

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

(Chemical Equation Presented) The synthesis of a protected dephosphofostriecin, and thereby a formal synthesis of fostriecin, has been accomplished. Two of the four chiral centers are controlled by an external chiral auxiliary and the other two are synthesized stereoselectively, one by a novel 1,4-asymmetric induction using cobalt-alkyne complex, and the other by 1,3-asymmetric induction.

Original languageEnglish
Pages (from-to)1405-1408
Number of pages4
JournalOrganic Letters
Volume10
Issue number7
DOIs
Publication statusPublished - 2008 Apr 3

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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    Hayashi, Y., Yamaguchi, H., Toyoshima, M., Okado, K., Toyo, T., & Shoji, M. (2008). Formal total synthesis of fostriecin via 1,4-asymmetric induction using cobalt-alkyne complex. Organic Letters, 10(7), 1405-1408. https://doi.org/10.1021/ol800195g