TY - JOUR
T1 - Formal Total Synthesis of l -Ossamine via Decarboxylative Functionalization Using Visible-Light-Mediated Photoredox Catalysis in a Flow System
AU - Inuki, Shinsuke
AU - Sato, Keisuke
AU - Fukuyama, Takahide
AU - Ryu, Ilhyong
AU - Fujimoto, Yukari
N1 - Funding Information:
This research was financially supported by grants from the Grant-in-Aid for Scientific Research (Nos. JP26282211, JP26102732, JP26882036, JP16H01162, and JP16K16638), the Mizutani Foundation for Glycoscience, and the Nagase Science Technology Foundation and Protein Research Foundation. We thank Prof. K. Suenaga for assistance in measuring the chiroptical data.
Publisher Copyright:
© 2016 American Chemical Society.
PY - 2017/1/20
Y1 - 2017/1/20
N2 - A formal total synthesis of l-ossamine was achieved. The key feature of the synthesis was the decarboxylative functionalization of a threonine derivative using visible-light-mediated photoredox catalysis. This reaction was implemented in a flow reactor, allowing for the efficient conversion to the desired product.
AB - A formal total synthesis of l-ossamine was achieved. The key feature of the synthesis was the decarboxylative functionalization of a threonine derivative using visible-light-mediated photoredox catalysis. This reaction was implemented in a flow reactor, allowing for the efficient conversion to the desired product.
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U2 - 10.1021/acs.joc.6b02531
DO - 10.1021/acs.joc.6b02531
M3 - Article
C2 - 27997795
AN - SCOPUS:85019383152
VL - 82
SP - 1248
EP - 1253
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
SN - 0022-3263
IS - 2
ER -