Formation of free radicals from steroid hormones

Possible significance in environmental carcinogenesis

Masahiko Kodama, F. Inoue, H. Saito, T. Oda, Y. Sato

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In order to clarify the mechanism of environmental carcinogenesis, steroid hormones were checked for formation of free radicals and active oxygen species. In alkaline DMSO in vitro, glucocorticoids, progestines, androgens and estrogens exhibited distinct ESR signals with characteristic hyperfine structures. Accumulated data on a great number of steroid derivatives suggest that an unpaired electron is localized at position 20 in the case of glucocorticoids, whereas it is at position 3 in other steroid hormones. Since experimental conditions include oxygenation reactions and more or less reflect enzymatic reactivity, the results obtained suggest further study on the physiological formation of free radicals from steroid hormone is warranted. Although detection of the free radicals of steroid hormones in several enzyme systems was limited to estrogens, evidence suggests that glucocorticoids as well as androgens may also share the physiological formation of free radicals. The production of active oxygen species was confirmed in certain cases.

Original languageEnglish
Pages (from-to)439-444
Number of pages6
JournalAnticancer Research
Volume17
Issue number1 A
Publication statusPublished - 1997

Fingerprint

Free Radicals
Carcinogenesis
Steroids
Hormones
Glucocorticoids
Androgens
Reactive Oxygen Species
Estrogens
Dimethyl Sulfoxide
Electrons
Enzymes

Keywords

  • Active oxygens
  • Environmental carcinogenesis
  • Free radicals
  • Redox balance
  • Steroid hormones

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kodama, M., Inoue, F., Saito, H., Oda, T., & Sato, Y. (1997). Formation of free radicals from steroid hormones: Possible significance in environmental carcinogenesis. Anticancer Research, 17(1 A), 439-444.

Formation of free radicals from steroid hormones : Possible significance in environmental carcinogenesis. / Kodama, Masahiko; Inoue, F.; Saito, H.; Oda, T.; Sato, Y.

In: Anticancer Research, Vol. 17, No. 1 A, 1997, p. 439-444.

Research output: Contribution to journalArticle

Kodama, M, Inoue, F, Saito, H, Oda, T & Sato, Y 1997, 'Formation of free radicals from steroid hormones: Possible significance in environmental carcinogenesis', Anticancer Research, vol. 17, no. 1 A, pp. 439-444.
Kodama, Masahiko ; Inoue, F. ; Saito, H. ; Oda, T. ; Sato, Y. / Formation of free radicals from steroid hormones : Possible significance in environmental carcinogenesis. In: Anticancer Research. 1997 ; Vol. 17, No. 1 A. pp. 439-444.
@article{26195ae51c39443c99cdcab2743eab6b,
title = "Formation of free radicals from steroid hormones: Possible significance in environmental carcinogenesis",
abstract = "In order to clarify the mechanism of environmental carcinogenesis, steroid hormones were checked for formation of free radicals and active oxygen species. In alkaline DMSO in vitro, glucocorticoids, progestines, androgens and estrogens exhibited distinct ESR signals with characteristic hyperfine structures. Accumulated data on a great number of steroid derivatives suggest that an unpaired electron is localized at position 20 in the case of glucocorticoids, whereas it is at position 3 in other steroid hormones. Since experimental conditions include oxygenation reactions and more or less reflect enzymatic reactivity, the results obtained suggest further study on the physiological formation of free radicals from steroid hormone is warranted. Although detection of the free radicals of steroid hormones in several enzyme systems was limited to estrogens, evidence suggests that glucocorticoids as well as androgens may also share the physiological formation of free radicals. The production of active oxygen species was confirmed in certain cases.",
keywords = "Active oxygens, Environmental carcinogenesis, Free radicals, Redox balance, Steroid hormones",
author = "Masahiko Kodama and F. Inoue and H. Saito and T. Oda and Y. Sato",
year = "1997",
language = "English",
volume = "17",
pages = "439--444",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "1 A",

}

TY - JOUR

T1 - Formation of free radicals from steroid hormones

T2 - Possible significance in environmental carcinogenesis

AU - Kodama, Masahiko

AU - Inoue, F.

AU - Saito, H.

AU - Oda, T.

AU - Sato, Y.

PY - 1997

Y1 - 1997

N2 - In order to clarify the mechanism of environmental carcinogenesis, steroid hormones were checked for formation of free radicals and active oxygen species. In alkaline DMSO in vitro, glucocorticoids, progestines, androgens and estrogens exhibited distinct ESR signals with characteristic hyperfine structures. Accumulated data on a great number of steroid derivatives suggest that an unpaired electron is localized at position 20 in the case of glucocorticoids, whereas it is at position 3 in other steroid hormones. Since experimental conditions include oxygenation reactions and more or less reflect enzymatic reactivity, the results obtained suggest further study on the physiological formation of free radicals from steroid hormone is warranted. Although detection of the free radicals of steroid hormones in several enzyme systems was limited to estrogens, evidence suggests that glucocorticoids as well as androgens may also share the physiological formation of free radicals. The production of active oxygen species was confirmed in certain cases.

AB - In order to clarify the mechanism of environmental carcinogenesis, steroid hormones were checked for formation of free radicals and active oxygen species. In alkaline DMSO in vitro, glucocorticoids, progestines, androgens and estrogens exhibited distinct ESR signals with characteristic hyperfine structures. Accumulated data on a great number of steroid derivatives suggest that an unpaired electron is localized at position 20 in the case of glucocorticoids, whereas it is at position 3 in other steroid hormones. Since experimental conditions include oxygenation reactions and more or less reflect enzymatic reactivity, the results obtained suggest further study on the physiological formation of free radicals from steroid hormone is warranted. Although detection of the free radicals of steroid hormones in several enzyme systems was limited to estrogens, evidence suggests that glucocorticoids as well as androgens may also share the physiological formation of free radicals. The production of active oxygen species was confirmed in certain cases.

KW - Active oxygens

KW - Environmental carcinogenesis

KW - Free radicals

KW - Redox balance

KW - Steroid hormones

UR - http://www.scopus.com/inward/record.url?scp=0031052783&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031052783&partnerID=8YFLogxK

M3 - Article

VL - 17

SP - 439

EP - 444

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 1 A

ER -