Formation of free radicals from steroid hormones: Possible significance in environmental carcinogenesis

Masahiko Kodama, F. Inoue, H. Saito, T. Oda, Y. Sato

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In order to clarify the mechanism of environmental carcinogenesis, steroid hormones were checked for formation of free radicals and active oxygen species. In alkaline DMSO in vitro, glucocorticoids, progestines, androgens and estrogens exhibited distinct ESR signals with characteristic hyperfine structures. Accumulated data on a great number of steroid derivatives suggest that an unpaired electron is localized at position 20 in the case of glucocorticoids, whereas it is at position 3 in other steroid hormones. Since experimental conditions include oxygenation reactions and more or less reflect enzymatic reactivity, the results obtained suggest further study on the physiological formation of free radicals from steroid hormone is warranted. Although detection of the free radicals of steroid hormones in several enzyme systems was limited to estrogens, evidence suggests that glucocorticoids as well as androgens may also share the physiological formation of free radicals. The production of active oxygen species was confirmed in certain cases.

Original languageEnglish
Pages (from-to)439-444
Number of pages6
JournalAnticancer research
Volume17
Issue number1 A
Publication statusPublished - 1997

Keywords

  • Active oxygens
  • Environmental carcinogenesis
  • Free radicals
  • Redox balance
  • Steroid hormones

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Kodama, M., Inoue, F., Saito, H., Oda, T., & Sato, Y. (1997). Formation of free radicals from steroid hormones: Possible significance in environmental carcinogenesis. Anticancer research, 17(1 A), 439-444.