Abstract
We report establishment of a nm-partial hydrophobic modification method by focused ion beam (FIB) and formation of parallel aqueous/organic two-phase flows in extended-nanochannels by control of liquid-liquid interface. Using the parallel two-phase flow, we demonstrated solvent extraction by integrating phase confluence, extraction and phase separation into 25 fL volume. Due to 103 times/sec interaction between solute molecules and surface by diffusion in 100 nm space, extraction of lipid into the organic phase was completed within 4.5 ms. The ultra high performance compared to microfluidics will greatly contribute to novel applications such as single cell analysis.
| Original language | English |
|---|---|
| Title of host publication | MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 1029-1031 |
| Number of pages | 3 |
| ISBN (Electronic) | 9780979806483 |
| Publication status | Published - 2015 Jan 1 |
| Event | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of Duration: 2015 Oct 25 → 2015 Oct 29 |
Publication series
| Name | MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
|---|
Other
| Other | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 |
|---|---|
| Country | Korea, Republic of |
| City | Gyeongju |
| Period | 15/10/25 → 15/10/29 |
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Keywords
- Extraction
- Nanofluidics
- Two-phase flow
ASJC Scopus subject areas
- Control and Systems Engineering
Cite this
Formation of parallel aq/org two-phase flows in extended-nanochannel by partial hydrophobic modification. / Kazoe, Yutaka; Ugajin, T.; Ohta, R.; Mawatari, K.; Kitamori, T.
MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2015. p. 1029-1031 (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Formation of parallel aq/org two-phase flows in extended-nanochannel by partial hydrophobic modification
AU - Kazoe, Yutaka
AU - Ugajin, T.
AU - Ohta, R.
AU - Mawatari, K.
AU - Kitamori, T.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - We report establishment of a nm-partial hydrophobic modification method by focused ion beam (FIB) and formation of parallel aqueous/organic two-phase flows in extended-nanochannels by control of liquid-liquid interface. Using the parallel two-phase flow, we demonstrated solvent extraction by integrating phase confluence, extraction and phase separation into 25 fL volume. Due to 103 times/sec interaction between solute molecules and surface by diffusion in 100 nm space, extraction of lipid into the organic phase was completed within 4.5 ms. The ultra high performance compared to microfluidics will greatly contribute to novel applications such as single cell analysis.
AB - We report establishment of a nm-partial hydrophobic modification method by focused ion beam (FIB) and formation of parallel aqueous/organic two-phase flows in extended-nanochannels by control of liquid-liquid interface. Using the parallel two-phase flow, we demonstrated solvent extraction by integrating phase confluence, extraction and phase separation into 25 fL volume. Due to 103 times/sec interaction between solute molecules and surface by diffusion in 100 nm space, extraction of lipid into the organic phase was completed within 4.5 ms. The ultra high performance compared to microfluidics will greatly contribute to novel applications such as single cell analysis.
KW - Extraction
KW - Nanofluidics
KW - Two-phase flow
UR - http://www.scopus.com/inward/record.url?scp=84983370852&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983370852&partnerID=8YFLogxK
M3 - Conference contribution
T3 - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 1029
EP - 1031
BT - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
ER -