TY - GEN
T1 - Formation of parallel aq/org two-phase flows in extended-nanochannel by partial hydrophobic modification
AU - Kazoe, Y.
AU - Ugajin, T.
AU - Ohta, R.
AU - Mawatari, K.
AU - Kitamori, T.
N1 - Funding Information:
This work was supported by Japan Science and Technology Agency, Core Research for Evolutional Science and Technology.
Publisher Copyright:
© 15CBMS-0001.
PY - 2015
Y1 - 2015
N2 - We report establishment of a nm-partial hydrophobic modification method by focused ion beam (FIB) and formation of parallel aqueous/organic two-phase flows in extended-nanochannels by control of liquid-liquid interface. Using the parallel two-phase flow, we demonstrated solvent extraction by integrating phase confluence, extraction and phase separation into 25 fL volume. Due to 103 times/sec interaction between solute molecules and surface by diffusion in 100 nm space, extraction of lipid into the organic phase was completed within 4.5 ms. The ultra high performance compared to microfluidics will greatly contribute to novel applications such as single cell analysis.
AB - We report establishment of a nm-partial hydrophobic modification method by focused ion beam (FIB) and formation of parallel aqueous/organic two-phase flows in extended-nanochannels by control of liquid-liquid interface. Using the parallel two-phase flow, we demonstrated solvent extraction by integrating phase confluence, extraction and phase separation into 25 fL volume. Due to 103 times/sec interaction between solute molecules and surface by diffusion in 100 nm space, extraction of lipid into the organic phase was completed within 4.5 ms. The ultra high performance compared to microfluidics will greatly contribute to novel applications such as single cell analysis.
KW - Extraction
KW - Nanofluidics
KW - Two-phase flow
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M3 - Conference contribution
AN - SCOPUS:84983370852
T3 - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 1029
EP - 1031
BT - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Y2 - 25 October 2015 through 29 October 2015
ER -