Formation of polymer microneedle arrays using soft lithography

Yoshimichi Ami, Hiroto Tachikawa, Naoki Takano, Norihisa Miki

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We demonstrate the fabrication of polymer microneedle arrays using soft lithography. A photomask was designed to use Fresnel diffraction of UV light to create sharp, tapered hollows in SU-8, a negative photoresist, after development. Polymer microneedles were formed using these SU-8 structures as a mold. These polymer needles may be applicable as flexible electrodes in brain-machine interfaces because they are more likely to survive movement of the skin than conventional brittle silicon needles. Similar needles, made from medicinal substances, could be used for transdermal drug administration. For these applications, the needles must be long, sharp, and stiff enough to penetrate the stratum corneum (∼20 m in thickness) and reach the viable epidermis (200-300 m in thickness), but must not reach the dermis, which contains sensitive nerve endings. We successfully manufactured 2020 microneedle arrays of polydimethylsiloxane with a needle length of 200 m. We experimentally verified that these manufactured electrodes successfully penetrated the stratum corneum of a cultured skin.

Original languageEnglish
Article number011503
JournalJournal of Micro/Nanolithography, MEMS, and MOEMS
Volume10
Issue number1
DOIs
Publication statusPublished - 2011

Fingerprint

needles
Needles
Lithography
Polymers
lithography
polymers
cornea
strata
Skin
epidermis
Photomasks
Fresnel diffraction
Electrodes
electrodes
photomasks
nerves
Silicon
Polydimethylsiloxane
Photoresists
photoresists

Keywords

  • brain-machine interfaces
  • drug delivery
  • microfabrication
  • microneedles
  • polymers

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Atomic and Molecular Physics, and Optics

Cite this

Formation of polymer microneedle arrays using soft lithography. / Ami, Yoshimichi; Tachikawa, Hiroto; Takano, Naoki; Miki, Norihisa.

In: Journal of Micro/Nanolithography, MEMS, and MOEMS, Vol. 10, No. 1, 011503, 2011.

Research output: Contribution to journalArticle

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