TY - JOUR
T1 - Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans
AU - Fujita, Suguru
AU - Karasawa, Yasuaki
AU - Fujii, Masashi
AU - Hironaka, Ken ichi
AU - Uda, Shinsuke
AU - Kubota, Hiroyuki
AU - Inoue, Hiroshi
AU - Sumitomo, Yohei
AU - Hirayama, Akiyoshi
AU - Soga, Tomoyoshi
AU - Kuroda, Shinya
N1 - Funding Information:
We thank our laboratory members for critical reading of the manuscript and technical assistance with the experiment and analysis. We thank Rika Sumita, Mina Shiguma, Ayae Aoki and Naomi Isene for technical assistance. We thank Kaori Igarashi, Hiroko Ueda, Maki Ohishi, Ayano Ueno, Keiko Endo, Mayu Honma, and Saya Sato (Keio University) for their technical assistance with metabolic analysis using CE-TOFMS. We thank for Neil M. Singer (Boldface Editors, Inc) for editing the manuscript. This work was supported by the Creation of Fundamental Technologies for Understanding and Control of Biosystem Dynamics (CREST; JPMJCR12W3) of the Japan Science and Technology Agency (JST) and by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Numbers 17H06299, 17H6300, 18H03979, and JP19K22860. Y.K. receives funding from JSPS KAKENHI Grant Numbers JP18K16578 and JP18H03125. M.F. receives funding from JSPS KAKENHI Grant Numbers JP16K12508 and JP19K20382. S.U. receives funding from JSPS KAKENHI and CREST Grant Numbers JP20H04847 and JPMJCR1912. H.K. receives funding from JSPS KAKENHI Grant Number JP16H06577. H.I. was supported by JSPS KAKENHI Grant Number JP18KT0020, JP20H04102, and JP20H04943. A.H. was supported by the JSPS KAKENHI Grant Number JP18H04804. T.S. receives funding from the Japan Agency for Medical Research and Development (AMED) and CREST under Grant Number JP21zf0127001 and JP18gm0710003. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funding Information:
We thank our laboratory members for critical reading of the manuscript and technical assistance with the experiment and analysis. We thank Rika Sumita, Mina Shiguma, Ayae Aoki and Naomi Isene for technical assistance. We thank Kaori Igarashi, Hiroko Ueda, Maki Ohishi, Ayano Ueno, Keiko Endo, Mayu Honma, and Saya Sato (Keio University) for their technical assistance with metabolic analysis using CE-TOFMS. We thank for Neil M. Singer (Boldface Editors, Inc) for editing the manuscript. This work was supported by the Creation of Fundamental Technologies for Understanding and Control of Biosystem Dynamics (CREST; JPMJCR12W3) of the Japan Science and Technology Agency (JST) and by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Numbers 17H06299, 17H6300, 18H03979, and JP19K22860. Y.K. receives funding from JSPS KAKENHI Grant Numbers JP18K16578 and JP18H03125. M.F. receives funding from JSPS KAKENHI Grant Numbers JP16K12508 and JP19K20382. S.U. receives funding from JSPS KAKENHI and CREST Grant Numbers JP20H04847 and JPMJCR1912. H.K. receives funding from JSPS KAKENHI Grant Number JP16H06577. H.I. was supported by JSPS KAKENHI Grant Number JP18KT0020, JP20H04102, and JP20H04943. A.H. was supported by the JSPS KAKENHI Grant Number JP18H04804. T.S. receives funding from the Japan Agency for Medical Research and Development (AMED) and CREST under Grant Number JP21zf0127001 and JP18gm0710003. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Oral glucose ingestion induces systemic changes of many blood metabolites related not only to glucose, but also other metabolites such as amino acids and lipids through many blood hormones. However, the detailed temporal changes in the concentrations of comprehensive metabolites and hormones over a long time by oral glucose ingestion are uncharacterized. We measured 83 metabolites and 7 hormones in 20 healthy human subjects in response to glucose ingestion. We characterized temporal patterns of blood molecules by four features: (i) the decomposability into “amplitude” and “rate” components, (ii) the similarity of temporal patterns among individuals, (iii) the relation of molecules over time among individuals, and (iv) the similarity of temporal patterns among molecules. Glucose and glucose metabolism-related hormones indicated a rapid increase, and citrulline and lipids, which indicated a rapid decrease, returned to fasting levels faster than amino acids. Compared to glucose metabolism-related molecules and lipids, amino acids showed similar temporal patterns among individuals. The four features of temporal patterns of blood molecules by oral glucose ingestion characterize the differences among individuals and among molecules.
AB - Oral glucose ingestion induces systemic changes of many blood metabolites related not only to glucose, but also other metabolites such as amino acids and lipids through many blood hormones. However, the detailed temporal changes in the concentrations of comprehensive metabolites and hormones over a long time by oral glucose ingestion are uncharacterized. We measured 83 metabolites and 7 hormones in 20 healthy human subjects in response to glucose ingestion. We characterized temporal patterns of blood molecules by four features: (i) the decomposability into “amplitude” and “rate” components, (ii) the similarity of temporal patterns among individuals, (iii) the relation of molecules over time among individuals, and (iv) the similarity of temporal patterns among molecules. Glucose and glucose metabolism-related hormones indicated a rapid increase, and citrulline and lipids, which indicated a rapid decrease, returned to fasting levels faster than amino acids. Compared to glucose metabolism-related molecules and lipids, amino acids showed similar temporal patterns among individuals. The four features of temporal patterns of blood molecules by oral glucose ingestion characterize the differences among individuals and among molecules.
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U2 - 10.1038/s41540-022-00213-0
DO - 10.1038/s41540-022-00213-0
M3 - Article
C2 - 35136093
AN - SCOPUS:85124288986
SN - 2056-7189
VL - 8
JO - npj Systems Biology and Applications
JF - npj Systems Biology and Applications
IS - 1
M1 - 6
ER -
