Four genes for the calpain family locate on four distinct human chromosomes

Shigeo Ohno, S. Minoshima, Jun Kudo, R. Fukuyama, Y. Shimizu, S. Ohmi-Imajoh, N. Shimizu, K. Suzuki

Research output: Contribution to journalArticle

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Abstract

Calcium dependent proteases (calpains. CAPNs, E.C.3.4.22.17) constitute a family of proteins which share a homologous cysteine-protease domain (large subunits. LI. L2. and L3) and an E-F hand Ca2+-binding domain (L1. L2. L3. and small subunit. S). We have mapped the genes for four calpain proteins (LI, L2, L3, and S) on four distinct human chromosomes by a combination of spot-blot hybridization to flow-sorted chromosomes and Southern hybridization of DNAs from a human × mouse hybrid cell panel. The genes for calpain LI (CAPN1. large subunit of calpain I). L2 (CAPN2, large subunit of calpain II), L3 (CAPN3. a protein related to the large subunits), and S (CAPN4. a small subunit common to calpains I and II) were assigned to human chromosomes 11, 1.15. and 19. respectively.

Original languageEnglish
Pages (from-to)225-229
Number of pages5
JournalCytogenetic and Genome Research
Volume53
Issue number4
DOIs
Publication statusPublished - 1990

Fingerprint

Calpain
Human Chromosomes
Genes
Chromosomes, Human, Pair 11
Proteins
Cysteine Proteases
Hybrid Cells
Peptide Hydrolases
Hand
Chromosomes
Calcium
DNA

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Genetics(clinical)
  • Cell Biology

Cite this

Ohno, S., Minoshima, S., Kudo, J., Fukuyama, R., Shimizu, Y., Ohmi-Imajoh, S., ... Suzuki, K. (1990). Four genes for the calpain family locate on four distinct human chromosomes. Cytogenetic and Genome Research, 53(4), 225-229. https://doi.org/10.1159/000132937

Four genes for the calpain family locate on four distinct human chromosomes. / Ohno, Shigeo; Minoshima, S.; Kudo, Jun; Fukuyama, R.; Shimizu, Y.; Ohmi-Imajoh, S.; Shimizu, N.; Suzuki, K.

In: Cytogenetic and Genome Research, Vol. 53, No. 4, 1990, p. 225-229.

Research output: Contribution to journalArticle

Ohno, S, Minoshima, S, Kudo, J, Fukuyama, R, Shimizu, Y, Ohmi-Imajoh, S, Shimizu, N & Suzuki, K 1990, 'Four genes for the calpain family locate on four distinct human chromosomes', Cytogenetic and Genome Research, vol. 53, no. 4, pp. 225-229. https://doi.org/10.1159/000132937
Ohno S, Minoshima S, Kudo J, Fukuyama R, Shimizu Y, Ohmi-Imajoh S et al. Four genes for the calpain family locate on four distinct human chromosomes. Cytogenetic and Genome Research. 1990;53(4):225-229. https://doi.org/10.1159/000132937
Ohno, Shigeo ; Minoshima, S. ; Kudo, Jun ; Fukuyama, R. ; Shimizu, Y. ; Ohmi-Imajoh, S. ; Shimizu, N. ; Suzuki, K. / Four genes for the calpain family locate on four distinct human chromosomes. In: Cytogenetic and Genome Research. 1990 ; Vol. 53, No. 4. pp. 225-229.
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