Four genes for the calpain family locate on four distinct human chromosomes

Shigeo Ohno, S. Minoshima, J. Kudoh, R. Fukuyama, Y. Shimizu, S. Ohmi-Imajoh, N. Shimizu, K. Suzuki

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Calcium dependent proteases (calpains. CAPNs, E.C. constitute a family of proteins which share a homologous cysteine-protease domain (large subunits. LI. L2. and L3) and an E-F hand Ca2+-binding domain (L1. L2. L3. and small subunit. S). We have mapped the genes for four calpain proteins (LI, L2, L3, and S) on four distinct human chromosomes by a combination of spot-blot hybridization to flow-sorted chromosomes and Southern hybridization of DNAs from a human × mouse hybrid cell panel. The genes for calpain LI (CAPN1. large subunit of calpain I). L2 (CAPN2, large subunit of calpain II), L3 (CAPN3. a protein related to the large subunits), and S (CAPN4. a small subunit common to calpains I and II) were assigned to human chromosomes 11, 1.15. and 19. respectively.

Original languageEnglish
Pages (from-to)225-229
Number of pages5
JournalCytogenetic and Genome Research
Issue number4
Publication statusPublished - 1990 Jan 1


ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Ohno, S., Minoshima, S., Kudoh, J., Fukuyama, R., Shimizu, Y., Ohmi-Imajoh, S., Shimizu, N., & Suzuki, K. (1990). Four genes for the calpain family locate on four distinct human chromosomes. Cytogenetic and Genome Research, 53(4), 225-229.