Four new macrocyclic trichothecenes from two strains of marine-derived fungi of the genus Myrothecium

Jinzhong Xu, Azusa Takasaki, Hisayoshi Kobayashi, Taiko Oda, Junko Yamada, Remy E P Mangindaan, Kazuyo Ukai, Hiroshi Nagai, Michio Namikoshi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Three new macrocyclic trichothecenes, named 12′-hydroxyroridin E (1), roridin Q (2), and 2′,3′-deoxyroritoxin D (3), were isolated from the marine-derived fungus Myrothecium roridum TUF 98F42, and a new macrocyclic trichothecene, named roridin R (4), was isolated from Myrothecium sp. TUF 02F6 together with roridins A and H and isororidin E. The structures of new compounds were determined on the basis of their spectral data. Compound 2 possessed a unique ether moiety at the 13′ position of 1. Compound 4 was a 2′,3′-dihydro-2′-hydroxy derivative of roridin H. The IC 50 values of compounds 1, 2, and 4 against the murine leukemia cell line L1210 were 0.19, 31.2, and 0.45 μM, respectively. Compound 3 showed antiyeast activity to Saccharomyces cerevisiae at 1 μg/disc (inhibition zone: 12.2mm), which was about 10 time more active than roritoxin D (10.2 mm at 10 μg/disc).

Original languageEnglish
Pages (from-to)451-455
Number of pages5
JournalJournal of Antibiotics
Volume59
Issue number8
Publication statusPublished - 2006 Aug

Fingerprint

Trichothecenes
Fungi
Ether
Saccharomyces cerevisiae
Leukemia
Cell Line
roridin H
roridin Q
roridin R
12'-hydroxyroridin E

Keywords

  • Cytotoxicity
  • L1210
  • Macrocyclic trichothecene
  • Marine-derived fungus
  • Myrothecium roridum
  • Roridin Q
  • Roridin R

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Xu, J., Takasaki, A., Kobayashi, H., Oda, T., Yamada, J., Mangindaan, R. E. P., ... Namikoshi, M. (2006). Four new macrocyclic trichothecenes from two strains of marine-derived fungi of the genus Myrothecium. Journal of Antibiotics, 59(8), 451-455.

Four new macrocyclic trichothecenes from two strains of marine-derived fungi of the genus Myrothecium. / Xu, Jinzhong; Takasaki, Azusa; Kobayashi, Hisayoshi; Oda, Taiko; Yamada, Junko; Mangindaan, Remy E P; Ukai, Kazuyo; Nagai, Hiroshi; Namikoshi, Michio.

In: Journal of Antibiotics, Vol. 59, No. 8, 08.2006, p. 451-455.

Research output: Contribution to journalArticle

Xu, J, Takasaki, A, Kobayashi, H, Oda, T, Yamada, J, Mangindaan, REP, Ukai, K, Nagai, H & Namikoshi, M 2006, 'Four new macrocyclic trichothecenes from two strains of marine-derived fungi of the genus Myrothecium', Journal of Antibiotics, vol. 59, no. 8, pp. 451-455.
Xu J, Takasaki A, Kobayashi H, Oda T, Yamada J, Mangindaan REP et al. Four new macrocyclic trichothecenes from two strains of marine-derived fungi of the genus Myrothecium. Journal of Antibiotics. 2006 Aug;59(8):451-455.
Xu, Jinzhong ; Takasaki, Azusa ; Kobayashi, Hisayoshi ; Oda, Taiko ; Yamada, Junko ; Mangindaan, Remy E P ; Ukai, Kazuyo ; Nagai, Hiroshi ; Namikoshi, Michio. / Four new macrocyclic trichothecenes from two strains of marine-derived fungi of the genus Myrothecium. In: Journal of Antibiotics. 2006 ; Vol. 59, No. 8. pp. 451-455.
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