Abstract
Three new macrocyclic trichothecenes, named 12′-hydroxyroridin E (1), roridin Q (2), and 2′,3′-deoxyroritoxin D (3), were isolated from the marine-derived fungus Myrothecium roridum TUF 98F42, and a new macrocyclic trichothecene, named roridin R (4), was isolated from Myrothecium sp. TUF 02F6 together with roridins A and H and isororidin E. The structures of new compounds were determined on the basis of their spectral data. Compound 2 possessed a unique ether moiety at the 13′ position of 1. Compound 4 was a 2′,3′-dihydro-2′-hydroxy derivative of roridin H. The IC 50 values of compounds 1, 2, and 4 against the murine leukemia cell line L1210 were 0.19, 31.2, and 0.45 μM, respectively. Compound 3 showed antiyeast activity to Saccharomyces cerevisiae at 1 μg/disc (inhibition zone: 12.2mm), which was about 10 time more active than roritoxin D (10.2 mm at 10 μg/disc).
| Original language | English |
|---|---|
| Pages (from-to) | 451-455 |
| Number of pages | 5 |
| Journal | Journal of Antibiotics |
| Volume | 59 |
| Issue number | 8 |
| Publication status | Published - 2006 Aug |
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Keywords
- Cytotoxicity
- L1210
- Macrocyclic trichothecene
- Marine-derived fungus
- Myrothecium roridum
- Roridin Q
- Roridin R
ASJC Scopus subject areas
- Pharmacology
- Molecular Medicine
Cite this
Four new macrocyclic trichothecenes from two strains of marine-derived fungi of the genus Myrothecium. / Xu, Jinzhong; Takasaki, Azusa; Kobayashi, Hisayoshi; Oda, Taiko; Yamada, Junko; Mangindaan, Remy E P; Ukai, Kazuyo; Nagai, Hiroshi; Namikoshi, Michio.
In: Journal of Antibiotics, Vol. 59, No. 8, 08.2006, p. 451-455.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Four new macrocyclic trichothecenes from two strains of marine-derived fungi of the genus Myrothecium
AU - Xu, Jinzhong
AU - Takasaki, Azusa
AU - Kobayashi, Hisayoshi
AU - Oda, Taiko
AU - Yamada, Junko
AU - Mangindaan, Remy E P
AU - Ukai, Kazuyo
AU - Nagai, Hiroshi
AU - Namikoshi, Michio
PY - 2006/8
Y1 - 2006/8
N2 - Three new macrocyclic trichothecenes, named 12′-hydroxyroridin E (1), roridin Q (2), and 2′,3′-deoxyroritoxin D (3), were isolated from the marine-derived fungus Myrothecium roridum TUF 98F42, and a new macrocyclic trichothecene, named roridin R (4), was isolated from Myrothecium sp. TUF 02F6 together with roridins A and H and isororidin E. The structures of new compounds were determined on the basis of their spectral data. Compound 2 possessed a unique ether moiety at the 13′ position of 1. Compound 4 was a 2′,3′-dihydro-2′-hydroxy derivative of roridin H. The IC 50 values of compounds 1, 2, and 4 against the murine leukemia cell line L1210 were 0.19, 31.2, and 0.45 μM, respectively. Compound 3 showed antiyeast activity to Saccharomyces cerevisiae at 1 μg/disc (inhibition zone: 12.2mm), which was about 10 time more active than roritoxin D (10.2 mm at 10 μg/disc).
AB - Three new macrocyclic trichothecenes, named 12′-hydroxyroridin E (1), roridin Q (2), and 2′,3′-deoxyroritoxin D (3), were isolated from the marine-derived fungus Myrothecium roridum TUF 98F42, and a new macrocyclic trichothecene, named roridin R (4), was isolated from Myrothecium sp. TUF 02F6 together with roridins A and H and isororidin E. The structures of new compounds were determined on the basis of their spectral data. Compound 2 possessed a unique ether moiety at the 13′ position of 1. Compound 4 was a 2′,3′-dihydro-2′-hydroxy derivative of roridin H. The IC 50 values of compounds 1, 2, and 4 against the murine leukemia cell line L1210 were 0.19, 31.2, and 0.45 μM, respectively. Compound 3 showed antiyeast activity to Saccharomyces cerevisiae at 1 μg/disc (inhibition zone: 12.2mm), which was about 10 time more active than roritoxin D (10.2 mm at 10 μg/disc).
KW - Cytotoxicity
KW - L1210
KW - Macrocyclic trichothecene
KW - Marine-derived fungus
KW - Myrothecium roridum
KW - Roridin Q
KW - Roridin R
UR - http://www.scopus.com/inward/record.url?scp=33749502215&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33749502215&partnerID=8YFLogxK
M3 - Article
C2 - 17080680
AN - SCOPUS:33749502215
VL - 59
SP - 451
EP - 455
JO - Journal of Antibiotics
JF - Journal of Antibiotics
SN - 0021-8820
IS - 8
ER -