TY - JOUR
T1 - Four new macrocyclic trichothecenes from two strains of marine-derived fungi of the genus Myrothecium
AU - Xu, Jinzhong
AU - Takasaki, Azusa
AU - Kobayashi, Hisayoshi
AU - Oda, Taiko
AU - Yamada, Junko
AU - Mangindaan, Remy E.P.
AU - Ukai, Kazuyo
AU - Nagai, Hiroshi
AU - Namikoshi, Michio
N1 - Funding Information:
Acknowledgements This work was supported in part by Grant-in-Aid for Scientific Research on Priority Areas 17035029 from The Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan to M. N. We are grateful to Dr. Y. Tsurumi of Fujisawa Pharmaceutical Co., Ltd. for the identification of the fungi. We also thank crewmembers of the training vessel Umitaka-maru for their generous help during the sample collection at Palau.
PY - 2006/8
Y1 - 2006/8
N2 - Three new macrocyclic trichothecenes, named 12′-hydroxyroridin E (1), roridin Q (2), and 2′,3′-deoxyroritoxin D (3), were isolated from the marine-derived fungus Myrothecium roridum TUF 98F42, and a new macrocyclic trichothecene, named roridin R (4), was isolated from Myrothecium sp. TUF 02F6 together with roridins A and H and isororidin E. The structures of new compounds were determined on the basis of their spectral data. Compound 2 possessed a unique ether moiety at the 13′ position of 1. Compound 4 was a 2′,3′-dihydro-2′-hydroxy derivative of roridin H. The IC 50 values of compounds 1, 2, and 4 against the murine leukemia cell line L1210 were 0.19, 31.2, and 0.45 μM, respectively. Compound 3 showed antiyeast activity to Saccharomyces cerevisiae at 1 μg/disc (inhibition zone: 12.2mm), which was about 10 time more active than roritoxin D (10.2 mm at 10 μg/disc).
AB - Three new macrocyclic trichothecenes, named 12′-hydroxyroridin E (1), roridin Q (2), and 2′,3′-deoxyroritoxin D (3), were isolated from the marine-derived fungus Myrothecium roridum TUF 98F42, and a new macrocyclic trichothecene, named roridin R (4), was isolated from Myrothecium sp. TUF 02F6 together with roridins A and H and isororidin E. The structures of new compounds were determined on the basis of their spectral data. Compound 2 possessed a unique ether moiety at the 13′ position of 1. Compound 4 was a 2′,3′-dihydro-2′-hydroxy derivative of roridin H. The IC 50 values of compounds 1, 2, and 4 against the murine leukemia cell line L1210 were 0.19, 31.2, and 0.45 μM, respectively. Compound 3 showed antiyeast activity to Saccharomyces cerevisiae at 1 μg/disc (inhibition zone: 12.2mm), which was about 10 time more active than roritoxin D (10.2 mm at 10 μg/disc).
KW - Cytotoxicity
KW - L1210
KW - Macrocyclic trichothecene
KW - Marine-derived fungus
KW - Myrothecium roridum
KW - Roridin Q
KW - Roridin R
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U2 - 10.1038/ja.2006.63
DO - 10.1038/ja.2006.63
M3 - Article
C2 - 17080680
AN - SCOPUS:33749502215
VL - 59
SP - 451
EP - 455
JO - Journal of Antibiotics
JF - Journal of Antibiotics
SN - 0021-8820
IS - 8
ER -
