Four new macrocyclic trichothecenes from two strains of marine-derived fungi of the genus Myrothecium

Jinzhong Xu, Azusa Takasaki, Hisayoshi Kobayashi, Taiko Oda, Junko Yamada, Remy E.P. Mangindaan, Kazuyo Ukai, Hiroshi Nagai, Michio Namikoshi

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Three new macrocyclic trichothecenes, named 12′-hydroxyroridin E (1), roridin Q (2), and 2′,3′-deoxyroritoxin D (3), were isolated from the marine-derived fungus Myrothecium roridum TUF 98F42, and a new macrocyclic trichothecene, named roridin R (4), was isolated from Myrothecium sp. TUF 02F6 together with roridins A and H and isororidin E. The structures of new compounds were determined on the basis of their spectral data. Compound 2 possessed a unique ether moiety at the 13′ position of 1. Compound 4 was a 2′,3′-dihydro-2′-hydroxy derivative of roridin H. The IC 50 values of compounds 1, 2, and 4 against the murine leukemia cell line L1210 were 0.19, 31.2, and 0.45 μM, respectively. Compound 3 showed antiyeast activity to Saccharomyces cerevisiae at 1 μg/disc (inhibition zone: 12.2mm), which was about 10 time more active than roritoxin D (10.2 mm at 10 μg/disc).

Original languageEnglish
Pages (from-to)451-455
Number of pages5
JournalJournal of Antibiotics
Volume59
Issue number8
DOIs
Publication statusPublished - 2006 Aug

Keywords

  • Cytotoxicity
  • L1210
  • Macrocyclic trichothecene
  • Marine-derived fungus
  • Myrothecium roridum
  • Roridin Q
  • Roridin R

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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  • Cite this

    Xu, J., Takasaki, A., Kobayashi, H., Oda, T., Yamada, J., Mangindaan, R. E. P., Ukai, K., Nagai, H., & Namikoshi, M. (2006). Four new macrocyclic trichothecenes from two strains of marine-derived fungi of the genus Myrothecium. Journal of Antibiotics, 59(8), 451-455. https://doi.org/10.1038/ja.2006.63