Free radical biology in digestive diseases

Yuji Naito, Makoto Suematsu, Toshikazu Yoshikawa

Research output: Book/ReportBook

Abstract

There is a growing body of experimental and clinical data to suggest that the organs of the digestive system may be subjected to considerable oxidative stress associated with acute and chronic inflammation. Although inflammation and ischemia play a key role in producing oxygen-derived free radicals in the digestive tract, the contribution of other factors, such as transition metal imbalances, lipid and glucose metabolic disturbance, and the interaction with gaseous molecules including nitric oxide and carbon monoxide, has also been suggested. Recent studies have demonstrated that several biomarkers indicating oxidative stress-mediated damage may help in monitoring the degree of disease and planning the design of new therapeutic strategies. In addition, recent advances in 'omics' research (genomics, proteomics, metabolomics, etc.) may bring a breakthrough in the field of gastroenterology and hepatology: Several molecular targets for oxidative stress have been presented by the 'omics'. This book includes up-to-date reviews on the relevant issues in free radical biology in a combination with expert basic research reviews and clinical aspects in gastroenterology and hepatology. Providing information about new molecular targets for the treatment or prevention of digestive diseases, this book should be read by clinical and basic researchers in gastroenterology and hepatology.

Original languageEnglish
PublisherS. Karger AG
Number of pages176
ISBN (Print)9783805596107, 9783805596091
DOIs
Publication statusPublished - 2010 Dec 21

Fingerprint

Gastroenterology
biology
free radicals
Free Radicals
Oxidative stress
digestive system
ischemia
Oxidative Stress
biomarkers
nitric oxide
glucose
organs
carbon monoxide
planning
lipids
disturbances
Digestive system
transition metals
Inflammation
damage

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Naito, Y., Suematsu, M., & Yoshikawa, T. (2010). Free radical biology in digestive diseases. S. Karger AG. https://doi.org/10.1159/isbn.978-3-8055-9610-7

Free radical biology in digestive diseases. / Naito, Yuji; Suematsu, Makoto; Yoshikawa, Toshikazu.

S. Karger AG, 2010. 176 p.

Research output: Book/ReportBook

Naito, Y, Suematsu, M & Yoshikawa, T 2010, Free radical biology in digestive diseases. S. Karger AG. https://doi.org/10.1159/isbn.978-3-8055-9610-7
Naito Y, Suematsu M, Yoshikawa T. Free radical biology in digestive diseases. S. Karger AG, 2010. 176 p. https://doi.org/10.1159/isbn.978-3-8055-9610-7
Naito, Yuji ; Suematsu, Makoto ; Yoshikawa, Toshikazu. / Free radical biology in digestive diseases. S. Karger AG, 2010. 176 p.
@book{e52e3e06446c44fb9a1dc181ebaecdf6,
title = "Free radical biology in digestive diseases",
abstract = "There is a growing body of experimental and clinical data to suggest that the organs of the digestive system may be subjected to considerable oxidative stress associated with acute and chronic inflammation. Although inflammation and ischemia play a key role in producing oxygen-derived free radicals in the digestive tract, the contribution of other factors, such as transition metal imbalances, lipid and glucose metabolic disturbance, and the interaction with gaseous molecules including nitric oxide and carbon monoxide, has also been suggested. Recent studies have demonstrated that several biomarkers indicating oxidative stress-mediated damage may help in monitoring the degree of disease and planning the design of new therapeutic strategies. In addition, recent advances in 'omics' research (genomics, proteomics, metabolomics, etc.) may bring a breakthrough in the field of gastroenterology and hepatology: Several molecular targets for oxidative stress have been presented by the 'omics'. This book includes up-to-date reviews on the relevant issues in free radical biology in a combination with expert basic research reviews and clinical aspects in gastroenterology and hepatology. Providing information about new molecular targets for the treatment or prevention of digestive diseases, this book should be read by clinical and basic researchers in gastroenterology and hepatology.",
author = "Yuji Naito and Makoto Suematsu and Toshikazu Yoshikawa",
year = "2010",
month = "12",
day = "21",
doi = "10.1159/isbn.978-3-8055-9610-7",
language = "English",
isbn = "9783805596107",
publisher = "S. Karger AG",

}

TY - BOOK

T1 - Free radical biology in digestive diseases

AU - Naito, Yuji

AU - Suematsu, Makoto

AU - Yoshikawa, Toshikazu

PY - 2010/12/21

Y1 - 2010/12/21

N2 - There is a growing body of experimental and clinical data to suggest that the organs of the digestive system may be subjected to considerable oxidative stress associated with acute and chronic inflammation. Although inflammation and ischemia play a key role in producing oxygen-derived free radicals in the digestive tract, the contribution of other factors, such as transition metal imbalances, lipid and glucose metabolic disturbance, and the interaction with gaseous molecules including nitric oxide and carbon monoxide, has also been suggested. Recent studies have demonstrated that several biomarkers indicating oxidative stress-mediated damage may help in monitoring the degree of disease and planning the design of new therapeutic strategies. In addition, recent advances in 'omics' research (genomics, proteomics, metabolomics, etc.) may bring a breakthrough in the field of gastroenterology and hepatology: Several molecular targets for oxidative stress have been presented by the 'omics'. This book includes up-to-date reviews on the relevant issues in free radical biology in a combination with expert basic research reviews and clinical aspects in gastroenterology and hepatology. Providing information about new molecular targets for the treatment or prevention of digestive diseases, this book should be read by clinical and basic researchers in gastroenterology and hepatology.

AB - There is a growing body of experimental and clinical data to suggest that the organs of the digestive system may be subjected to considerable oxidative stress associated with acute and chronic inflammation. Although inflammation and ischemia play a key role in producing oxygen-derived free radicals in the digestive tract, the contribution of other factors, such as transition metal imbalances, lipid and glucose metabolic disturbance, and the interaction with gaseous molecules including nitric oxide and carbon monoxide, has also been suggested. Recent studies have demonstrated that several biomarkers indicating oxidative stress-mediated damage may help in monitoring the degree of disease and planning the design of new therapeutic strategies. In addition, recent advances in 'omics' research (genomics, proteomics, metabolomics, etc.) may bring a breakthrough in the field of gastroenterology and hepatology: Several molecular targets for oxidative stress have been presented by the 'omics'. This book includes up-to-date reviews on the relevant issues in free radical biology in a combination with expert basic research reviews and clinical aspects in gastroenterology and hepatology. Providing information about new molecular targets for the treatment or prevention of digestive diseases, this book should be read by clinical and basic researchers in gastroenterology and hepatology.

UR - http://www.scopus.com/inward/record.url?scp=84925860448&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925860448&partnerID=8YFLogxK

U2 - 10.1159/isbn.978-3-8055-9610-7

DO - 10.1159/isbn.978-3-8055-9610-7

M3 - Book

AN - SCOPUS:84925860448

SN - 9783805596107

SN - 9783805596091

BT - Free radical biology in digestive diseases

PB - S. Karger AG

ER -