Frequencies of spontaneous breast development and spontaneous menarche in turner syndrome in Japan

Toshiaki Tanaka, Yutaka Igarashi, Keiichi Ozono, Kenji Ohyama, Masamichi Ogawa, Hisao Osada, Kazumichi Onigata, Susumu Kanzaki, Hitoshi Kohno, Yoshiki Seino, Hiroaki Takahashi, Toshihiro Tajima, Katsuhiko Tachibana, Hiroyuki Tanaka, Yoshikazu Nishi, Tomonobu Hasegawa, Keinosuke Fujita, Tohru Yorifuji, Reiko Horikawa, Susumu Yokoya

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16 Citations (Scopus)

Abstract

The Growject® database on human GH treatment in Turner syndrome was analyzed in the Turner Syndrome Research Collaboration, and the relationships of the frequencies of spontaneous breast development and spontaneous menarche with karyotype and GH treatment were investigated. One hundred and three cases started GH treatment with 0.5 IU/kg/ week (0.5 IU group), and their dose was increased to 0.35 mg/kg/wk midway through the treatment course. Another 109 cases started GH at a dose of 0.35 mg/kg/wk (0.35 mg group). Spontaneous breast development was observed in 77 (36.3%) of the 212 patients, and spontaneous menarche occurred in 31 patients (14.6%). The frequency of spontaneous breast development was significantly lower in patients with the 45,X karyotype and significantly higher in patients with a structural abnormality of the second X chromosome. The frequency of spontaneous menarche was significantly higher in patients with mosaicism characterized by X monosomy and a cellular line with no structural abnormality of the X chromosome. No significant differences in frequencies of spontaneous breast development and spontaneous menarche were observed between the two dose groups, indicating that GH treatment does not increase the frequency of spontaneous puberty.

Original languageEnglish
Pages (from-to)167-173
Number of pages7
Journalclinical pediatric endocrinology
Volume24
Issue number4
DOIs
Publication statusPublished - 2015 Oct 24

Keywords

  • Chromosome
  • GH treatment
  • Spontaneous breast development
  • Spontaneous menarche
  • Turner syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Tanaka, T., Igarashi, Y., Ozono, K., Ohyama, K., Ogawa, M., Osada, H., Onigata, K., Kanzaki, S., Kohno, H., Seino, Y., Takahashi, H., Tajima, T., Tachibana, K., Tanaka, H., Nishi, Y., Hasegawa, T., Fujita, K., Yorifuji, T., Horikawa, R., & Yokoya, S. (2015). Frequencies of spontaneous breast development and spontaneous menarche in turner syndrome in Japan. clinical pediatric endocrinology, 24(4), 167-173. https://doi.org/10.1297/cpe.24.167