Frequencies of spontaneous breast development and spontaneous menarche in turner syndrome in Japan

Toshiaki Tanaka, Yutaka Igarashi, Keiichi Ozono, Kenji Ohyama, Masamichi Ogawa, Hisao Osada, Kazumichi Onigata, Susumu Kanzaki, Hitoshi Kohno, Yoshiki Seino, Hiroaki Takahashi, Toshihiro Tajima, Katsuhiko Tachibana, Hiroyuki Tanaka, Yoshikazu Nishi, Tomonobu Hasegawa, Keinosuke Fujita, Tohru Yorifuji, Reiko Horikawa, Susumu Yokoya

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The Growject® database on human GH treatment in Turner syndrome was analyzed in the Turner Syndrome Research Collaboration, and the relationships of the frequencies of spontaneous breast development and spontaneous menarche with karyotype and GH treatment were investigated. One hundred and three cases started GH treatment with 0.5 IU/kg/ week (0.5 IU group), and their dose was increased to 0.35 mg/kg/wk midway through the treatment course. Another 109 cases started GH at a dose of 0.35 mg/kg/wk (0.35 mg group). Spontaneous breast development was observed in 77 (36.3%) of the 212 patients, and spontaneous menarche occurred in 31 patients (14.6%). The frequency of spontaneous breast development was significantly lower in patients with the 45,X karyotype and significantly higher in patients with a structural abnormality of the second X chromosome. The frequency of spontaneous menarche was significantly higher in patients with mosaicism characterized by X monosomy and a cellular line with no structural abnormality of the X chromosome. No significant differences in frequencies of spontaneous breast development and spontaneous menarche were observed between the two dose groups, indicating that GH treatment does not increase the frequency of spontaneous puberty.

Original languageEnglish
Pages (from-to)167-173
Number of pages7
JournalClinical Pediatric Endocrinology
Volume24
Issue number4
DOIs
Publication statusPublished - 2015 Oct 24

Fingerprint

Turner Syndrome
Menarche
Japan
Breast
X Chromosome
Karyotype
Therapeutics
Mosaicism
Puberty
Databases
Research

Keywords

  • Chromosome
  • GH treatment
  • Spontaneous breast development
  • Spontaneous menarche
  • Turner syndrome

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

Cite this

Tanaka, T., Igarashi, Y., Ozono, K., Ohyama, K., Ogawa, M., Osada, H., ... Yokoya, S. (2015). Frequencies of spontaneous breast development and spontaneous menarche in turner syndrome in Japan. Clinical Pediatric Endocrinology, 24(4), 167-173. https://doi.org/10.1297/cpe.24.167

Frequencies of spontaneous breast development and spontaneous menarche in turner syndrome in Japan. / Tanaka, Toshiaki; Igarashi, Yutaka; Ozono, Keiichi; Ohyama, Kenji; Ogawa, Masamichi; Osada, Hisao; Onigata, Kazumichi; Kanzaki, Susumu; Kohno, Hitoshi; Seino, Yoshiki; Takahashi, Hiroaki; Tajima, Toshihiro; Tachibana, Katsuhiko; Tanaka, Hiroyuki; Nishi, Yoshikazu; Hasegawa, Tomonobu; Fujita, Keinosuke; Yorifuji, Tohru; Horikawa, Reiko; Yokoya, Susumu.

In: Clinical Pediatric Endocrinology, Vol. 24, No. 4, 24.10.2015, p. 167-173.

Research output: Contribution to journalArticle

Tanaka, T, Igarashi, Y, Ozono, K, Ohyama, K, Ogawa, M, Osada, H, Onigata, K, Kanzaki, S, Kohno, H, Seino, Y, Takahashi, H, Tajima, T, Tachibana, K, Tanaka, H, Nishi, Y, Hasegawa, T, Fujita, K, Yorifuji, T, Horikawa, R & Yokoya, S 2015, 'Frequencies of spontaneous breast development and spontaneous menarche in turner syndrome in Japan', Clinical Pediatric Endocrinology, vol. 24, no. 4, pp. 167-173. https://doi.org/10.1297/cpe.24.167
Tanaka, Toshiaki ; Igarashi, Yutaka ; Ozono, Keiichi ; Ohyama, Kenji ; Ogawa, Masamichi ; Osada, Hisao ; Onigata, Kazumichi ; Kanzaki, Susumu ; Kohno, Hitoshi ; Seino, Yoshiki ; Takahashi, Hiroaki ; Tajima, Toshihiro ; Tachibana, Katsuhiko ; Tanaka, Hiroyuki ; Nishi, Yoshikazu ; Hasegawa, Tomonobu ; Fujita, Keinosuke ; Yorifuji, Tohru ; Horikawa, Reiko ; Yokoya, Susumu. / Frequencies of spontaneous breast development and spontaneous menarche in turner syndrome in Japan. In: Clinical Pediatric Endocrinology. 2015 ; Vol. 24, No. 4. pp. 167-173.
@article{0d71ede5a8b1437c9c179c52be9e255b,
title = "Frequencies of spontaneous breast development and spontaneous menarche in turner syndrome in Japan",
abstract = "The Growject{\circledR} database on human GH treatment in Turner syndrome was analyzed in the Turner Syndrome Research Collaboration, and the relationships of the frequencies of spontaneous breast development and spontaneous menarche with karyotype and GH treatment were investigated. One hundred and three cases started GH treatment with 0.5 IU/kg/ week (0.5 IU group), and their dose was increased to 0.35 mg/kg/wk midway through the treatment course. Another 109 cases started GH at a dose of 0.35 mg/kg/wk (0.35 mg group). Spontaneous breast development was observed in 77 (36.3{\%}) of the 212 patients, and spontaneous menarche occurred in 31 patients (14.6{\%}). The frequency of spontaneous breast development was significantly lower in patients with the 45,X karyotype and significantly higher in patients with a structural abnormality of the second X chromosome. The frequency of spontaneous menarche was significantly higher in patients with mosaicism characterized by X monosomy and a cellular line with no structural abnormality of the X chromosome. No significant differences in frequencies of spontaneous breast development and spontaneous menarche were observed between the two dose groups, indicating that GH treatment does not increase the frequency of spontaneous puberty.",
keywords = "Chromosome, GH treatment, Spontaneous breast development, Spontaneous menarche, Turner syndrome",
author = "Toshiaki Tanaka and Yutaka Igarashi and Keiichi Ozono and Kenji Ohyama and Masamichi Ogawa and Hisao Osada and Kazumichi Onigata and Susumu Kanzaki and Hitoshi Kohno and Yoshiki Seino and Hiroaki Takahashi and Toshihiro Tajima and Katsuhiko Tachibana and Hiroyuki Tanaka and Yoshikazu Nishi and Tomonobu Hasegawa and Keinosuke Fujita and Tohru Yorifuji and Reiko Horikawa and Susumu Yokoya",
year = "2015",
month = "10",
day = "24",
doi = "10.1297/cpe.24.167",
language = "English",
volume = "24",
pages = "167--173",
journal = "Clinical Pediatric Endocrinology",
issn = "0918-5739",
publisher = "Jeff Corporation Co. Ltd",
number = "4",

}

TY - JOUR

T1 - Frequencies of spontaneous breast development and spontaneous menarche in turner syndrome in Japan

AU - Tanaka, Toshiaki

AU - Igarashi, Yutaka

AU - Ozono, Keiichi

AU - Ohyama, Kenji

AU - Ogawa, Masamichi

AU - Osada, Hisao

AU - Onigata, Kazumichi

AU - Kanzaki, Susumu

AU - Kohno, Hitoshi

AU - Seino, Yoshiki

AU - Takahashi, Hiroaki

AU - Tajima, Toshihiro

AU - Tachibana, Katsuhiko

AU - Tanaka, Hiroyuki

AU - Nishi, Yoshikazu

AU - Hasegawa, Tomonobu

AU - Fujita, Keinosuke

AU - Yorifuji, Tohru

AU - Horikawa, Reiko

AU - Yokoya, Susumu

PY - 2015/10/24

Y1 - 2015/10/24

N2 - The Growject® database on human GH treatment in Turner syndrome was analyzed in the Turner Syndrome Research Collaboration, and the relationships of the frequencies of spontaneous breast development and spontaneous menarche with karyotype and GH treatment were investigated. One hundred and three cases started GH treatment with 0.5 IU/kg/ week (0.5 IU group), and their dose was increased to 0.35 mg/kg/wk midway through the treatment course. Another 109 cases started GH at a dose of 0.35 mg/kg/wk (0.35 mg group). Spontaneous breast development was observed in 77 (36.3%) of the 212 patients, and spontaneous menarche occurred in 31 patients (14.6%). The frequency of spontaneous breast development was significantly lower in patients with the 45,X karyotype and significantly higher in patients with a structural abnormality of the second X chromosome. The frequency of spontaneous menarche was significantly higher in patients with mosaicism characterized by X monosomy and a cellular line with no structural abnormality of the X chromosome. No significant differences in frequencies of spontaneous breast development and spontaneous menarche were observed between the two dose groups, indicating that GH treatment does not increase the frequency of spontaneous puberty.

AB - The Growject® database on human GH treatment in Turner syndrome was analyzed in the Turner Syndrome Research Collaboration, and the relationships of the frequencies of spontaneous breast development and spontaneous menarche with karyotype and GH treatment were investigated. One hundred and three cases started GH treatment with 0.5 IU/kg/ week (0.5 IU group), and their dose was increased to 0.35 mg/kg/wk midway through the treatment course. Another 109 cases started GH at a dose of 0.35 mg/kg/wk (0.35 mg group). Spontaneous breast development was observed in 77 (36.3%) of the 212 patients, and spontaneous menarche occurred in 31 patients (14.6%). The frequency of spontaneous breast development was significantly lower in patients with the 45,X karyotype and significantly higher in patients with a structural abnormality of the second X chromosome. The frequency of spontaneous menarche was significantly higher in patients with mosaicism characterized by X monosomy and a cellular line with no structural abnormality of the X chromosome. No significant differences in frequencies of spontaneous breast development and spontaneous menarche were observed between the two dose groups, indicating that GH treatment does not increase the frequency of spontaneous puberty.

KW - Chromosome

KW - GH treatment

KW - Spontaneous breast development

KW - Spontaneous menarche

KW - Turner syndrome

UR - http://www.scopus.com/inward/record.url?scp=84944892457&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944892457&partnerID=8YFLogxK

U2 - 10.1297/cpe.24.167

DO - 10.1297/cpe.24.167

M3 - Article

AN - SCOPUS:84944892457

VL - 24

SP - 167

EP - 173

JO - Clinical Pediatric Endocrinology

JF - Clinical Pediatric Endocrinology

SN - 0918-5739

IS - 4

ER -