Frequency of anti-centromere antibodies in the anti-mitochondrial antibody positive sera

T. Okano, Michito Hirakata, T. Mimori, M. Akizuki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Autoantibodies give us useful informations for the understanding of the co-existence of multiple autoimmune diseases in an individual patient. This study was undertaken to clarify the frequency of anti-centromere antibodies in the sera which were positive for anti-mitochondrial antibodies. Serum samples with anti-mitochondrial antibodies were examined on the frozen rat liver section and HEp-2 cells by indirect immunofluorescence. 57 out of 239 anti-mitochondrial antibody positive sera were found to contain specific autoantibodies reactive with centromeric antigens of the HEp-2 chromosomal spreads. The co-existence of anticentromere antibodies with anti-mitochondrial antibodies were significantly more frequent than with other defined autoantibodies. Clinical observation which shows frequent association of CREST syndrome and primary biliary cirrhosis appear to be explained by the frequent occurrence of anti-centromere antibodies and anti-mitochondrial antibodies.

Original languageEnglish
Pages (from-to)1367-1372
Number of pages6
JournalRinsho byori. The Japanese journal of clinical pathology
Volume37
Issue number12
Publication statusPublished - 1989 Dec
Externally publishedYes

Fingerprint

Centromere
Anti-Idiotypic Antibodies
Serum
Autoantibodies
CREST Syndrome
Biliary Liver Cirrhosis
Indirect Fluorescent Antibody Technique
Autoimmune Diseases
Observation
Antigens
Liver

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Frequency of anti-centromere antibodies in the anti-mitochondrial antibody positive sera. / Okano, T.; Hirakata, Michito; Mimori, T.; Akizuki, M.

In: Rinsho byori. The Japanese journal of clinical pathology, Vol. 37, No. 12, 12.1989, p. 1367-1372.

Research output: Contribution to journalArticle

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