Frequency-specific synchronization in the bilateral subthalamic nuclei depending on voluntary muscle contraction and relaxation in patients with parkinson’s disease

Kenji Kato, Fusako Yokochi, Hirokazu Iwamuro, Takashi Kawasaki, Kohichi Hamada, Ayako Isoo, Katsuo Kimura, Ryoichi Okiyama, Makoto Taniguchi, Junichi Ushiba

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The volitional control of muscle contraction and relaxation is a fundamental component of human motor activity, but how the processing of the subcortical networks, including the subthalamic nucleus (STN), is involved in voluntary muscle contraction (VMC) and voluntary muscle relaxation (VMR) remains unclear. In this study, local field potentials (LFPs) of bilateral STNs were recorded in patients with Parkinson’s disease (PD) while performing externally paced VMC and VMR tasks of the unilateral wrist extensor muscle. The VMC-or VMR-related oscillatory activities and their functional couplings were investigated over the theta (4-7 Hz), alpha (8-13 Hz), beta (14-35 Hz), and gamma (40-100 Hz) frequency bands. Alpha and beta desynchronizations were observed in bilateral STNs at the onset of both VMC and VMR tasks. On the other hand, theta and gamma synchronizations were prominent in bilateral STNs specifically at the onset of the VMC task. In particular, just after VMC, theta functional coupling between the bilateral STNs increased, and the theta phase became coupled to the gamma amplitude within the contralateral STN in a phase-amplitude cross-frequency coupled manner. On the other hand, the prominent beta-gamma cross-frequency couplings observed in the bilateral STNs at rest were reduced by the VMC and VMR tasks. These results suggest that STNs are bilaterally involved in the different performances of muscle contraction and relaxation through the theta-gamma and beta-gamma networks between bilateral STNs in patients with PD.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalFrontiers in Human Neuroscience
Volume10
Issue numberMAR2016
DOIs
Publication statusPublished - 2016 Mar 30

Fingerprint

Subthalamic Nucleus
Muscle Relaxation
Muscle Contraction
Parkinson Disease
Skeletal Muscle
Wrist
Human Activities
Motor Activity

Keywords

  • Coherence
  • Cross-frequency coupling
  • Deep brain stimulation
  • Neuronal oscillations
  • Parkinson’s disease
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Frequency-specific synchronization in the bilateral subthalamic nuclei depending on voluntary muscle contraction and relaxation in patients with parkinson’s disease. / Kato, Kenji; Yokochi, Fusako; Iwamuro, Hirokazu; Kawasaki, Takashi; Hamada, Kohichi; Isoo, Ayako; Kimura, Katsuo; Okiyama, Ryoichi; Taniguchi, Makoto; Ushiba, Junichi.

In: Frontiers in Human Neuroscience, Vol. 10, No. MAR2016, 30.03.2016, p. 1-13.

Research output: Contribution to journalArticle

Kato, Kenji ; Yokochi, Fusako ; Iwamuro, Hirokazu ; Kawasaki, Takashi ; Hamada, Kohichi ; Isoo, Ayako ; Kimura, Katsuo ; Okiyama, Ryoichi ; Taniguchi, Makoto ; Ushiba, Junichi. / Frequency-specific synchronization in the bilateral subthalamic nuclei depending on voluntary muscle contraction and relaxation in patients with parkinson’s disease. In: Frontiers in Human Neuroscience. 2016 ; Vol. 10, No. MAR2016. pp. 1-13.
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