Frequent BRAF or EGFR mutations in ciliated muconodular papillary tumors of the lung

Tsugumasa Kamata, Kuniko Sunami, Akihiko Yoshida, Kouya Shiraishi, Koh Furuta, Yoko Shimada, Hitoshi Katai, Shun Ichi Watanabe, Hisao Asamura, Takashi Kohno, Koji Tsuta

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Abstract

Introduction: Ciliated muconodular papillary tumors (CMPTs) are recently characterized, rare peripheral nodules of the lung. These small tumors are histologically comprised of a vaguely organized mixture of nonatypical ciliated columnar cells, mucous cells, and basal cells, and consistently follow a benign clinical course. However, the histogenesis of CMPTs remains uncertain. Methods: We performed detailed genomic analyses of 10 archived CMPT cases, using next-generation sequencing and high-resolution melting analysis. Results: Mutations were identified in eight of the 10 cases (80%); four cases harbored the BRAF-V600E mutation, one case harbored the BRAF-G606R mutation, and three cases harbored deletions in exon 19 of EGFR. All of the deletions in EGFR were of the E746-T751/S752V subtype. Conclusions: The high prevalence of driver gene mutations in CMPTs supports the notion that these lesions are neoplastic rather than reactive or metaplastic.

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalJournal of Thoracic Oncology
Volume11
Issue number2
DOIs
Publication statusPublished - 2016

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Keywords

  • BRAF
  • Ciliated muconodular papillary tumors
  • EGFR
  • Histogenesis
  • Next-generation sequencing

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Kamata, T., Sunami, K., Yoshida, A., Shiraishi, K., Furuta, K., Shimada, Y., Katai, H., Watanabe, S. I., Asamura, H., Kohno, T., & Tsuta, K. (2016). Frequent BRAF or EGFR mutations in ciliated muconodular papillary tumors of the lung. Journal of Thoracic Oncology, 11(2), 261-265. https://doi.org/10.1016/j.jtho.2015.10.021