FSTL1 promotes bone metastasis by causing immune dysfunction

Chie Kudo-Saito

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In spite of significant advances in our understanding of the metastatic process, the relationship between the dissemination of primary neoplasms to the bones and antitumor immunity remains poorly understood. We have recently identified follistatin-like 1 (FSTL1), a soluble protein secreted by snail family zinc finger 1 (SNAI1)-expressing cancer cells, as a key determinant of bone metastasis that operates by inducing a systemic state of immune dysfunction.

Original languageEnglish
Article numbere26528
JournalOncoImmunology
Volume2
Issue number11
DOIs
Publication statusPublished - 2013

Fingerprint

Follistatin
Bone Neoplasms
Zinc Fingers
Snails
Immunity
Neoplasm Metastasis
Bone and Bones
Neoplasms
Proteins

Keywords

  • ALCAM
  • Bone metastasis
  • FSTL1
  • Mesenchymal stem cell
  • SNAIL

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Cite this

FSTL1 promotes bone metastasis by causing immune dysfunction. / Kudo-Saito, Chie.

In: OncoImmunology, Vol. 2, No. 11, e26528, 2013.

Research output: Contribution to journalArticle

Kudo-Saito, Chie. / FSTL1 promotes bone metastasis by causing immune dysfunction. In: OncoImmunology. 2013 ; Vol. 2, No. 11.
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