Fully inkjet-printed distance-based paper microfluidic devices for colorimetric calcium determination using ion-selective optodes

Hiroyuki Shibata, Yuki Hiruta, Daniel Citterio

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Although the determination of calcium ions (Ca 2+ ) is of high importance to monitor water hardness, currently available devices for on-site analysis suffer from a lack of user-friendliness and sensitivity. This work demonstrates fully inkjet-printed and low-cost microfluidic paper-based analytical devices (μPADs) for the simple naked-eye colorimetric determination of calcium ions (Ca 2+ ) in drinking and tap water samples. The quantification of Ca 2+ relies on visual readout of the length of a colour-changed detection channel modified with ionophore-doped ion-selective optode nanospheres (nano-optodes), eliminating the requirement of a scanner or a camera. All fabrication steps for deposition of assay reagents have been performed by means of a simple desktop thermal inkjet printer, which is expected to contribute to highly batch-to-batch reproducible device preparation. The detectable Ca 2+ concentrations between 0.05 mmol L -1 and 5 mmol L -1 cover the range recommended by the International Organization for Standardization (0.05-2.5 mmol L -1 ) and the World Health Organization (WHO) guideline for Ca 2+ quantification in drinking water (less than 5 mmol L -1 ). The lowest concentration of Ca 2+ detectable by the naked eye was found to be 0.05 mmol L -1 , which is below the value achieved with previously reported paper-based devices. μPAD quantified Ca 2+ concentrations in tap or drinking waters were within 15% error of the results obtained with a classical complexometric titration. Hence, distance-based μPADs relying on nano-optodes are sensitive and reproducible tools for equipment-free on-site assaying of Ca 2+ in real samples.

Original languageEnglish
Pages (from-to)1178-1186
Number of pages9
JournalAnalyst
Volume144
Issue number4
DOIs
Publication statusPublished - 2019 Feb 21

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Lab-On-A-Chip Devices
Microfluidics
Calcium
calcium
Ions
Potable water
Drinking Water
Equipment and Supplies
ion
Water hardness
drinking water
Ionophores
Nanospheres
international organization
World Health Organization
drinking
scanner
Titration
standardization
Standardization

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry

Cite this

Fully inkjet-printed distance-based paper microfluidic devices for colorimetric calcium determination using ion-selective optodes. / Shibata, Hiroyuki; Hiruta, Yuki; Citterio, Daniel.

In: Analyst, Vol. 144, No. 4, 21.02.2019, p. 1178-1186.

Research output: Contribution to journalArticle

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