Fulminant hepatic failure caused by adenovirus infection mimicking peliosis hepatitis on abdominal computed tomography images after allogeneic hematopoietic stem cell transplantation

Kiriko Terasako, Kumi Oshima, Hidenori Wada, Yuko Ishihara, Koji Kawamura, Kana Sakamoto, Masahiro Ashizawa, Miki Sato, Tomohito Machishima, Hideki Nakasone, Shun Ichi Kimura, Misato Kikuchi, Shinya Okuda, Shinichi Kako, Rie Yamazaki, Kengo Takeuchi, Junji Nishida, Shigeki Yamada, Osamu Tanaka, Yoshinobu Kanda

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Disseminated adenovirus disease after allogeneic hematopoietic stem cell transplantation (HSCT) is lethal in most cases, especially when it develops as fulminant hepatic failure. We encountered a patient who developed fulminant hepatic failure caused by adenovirus infection. She did not show manifestations of graftversus-host disease and the results of serum tests for viral infection were all negative. Abdominal computed tomography (CT) findings were consistent with peliosis hepatitis. She died of fulminant hepatic failure, however, and pathological examinations of the liver specimen obtained after her death revealed adenovirus infection. In this report, we review the clinical characteristics and imaging findings of fulminant hepatic failure caused by adenovirus infection.

Original languageEnglish
Pages (from-to)405-411
Number of pages7
JournalInternal Medicine
Volume51
Issue number4
DOIs
Publication statusPublished - 2012 Feb 23
Externally publishedYes

Keywords

  • Adenovirus
  • Fulminant hepatic failure
  • Hematopoietic stem cell transplantation
  • Peliosis hepatitis

ASJC Scopus subject areas

  • Internal Medicine

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  • Cite this

    Terasako, K., Oshima, K., Wada, H., Ishihara, Y., Kawamura, K., Sakamoto, K., Ashizawa, M., Sato, M., Machishima, T., Nakasone, H., Kimura, S. I., Kikuchi, M., Okuda, S., Kako, S., Yamazaki, R., Takeuchi, K., Nishida, J., Yamada, S., Tanaka, O., & Kanda, Y. (2012). Fulminant hepatic failure caused by adenovirus infection mimicking peliosis hepatitis on abdominal computed tomography images after allogeneic hematopoietic stem cell transplantation. Internal Medicine, 51(4), 405-411. https://doi.org/10.2169/internalmedicine.51.6432