Function and structural regulation of the carbon monoxide (CO)-responsive membrane protein PGRMC1

Yasuaki Kabe, Hiroshi Handa, Makoto Suematsu

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Progesterone receptor membrance associated component 1 is a multifunctional heme-binding protein that plays a role in several biological processes such as tumor progression, metabolic regulation, and viability control of nerve cells. Notably, progesterone receptor membrane associated component 1 is highly expressed in various types of cancer cells, and facilitates cancer proliferation and chemoresistance. Recently, progesterone receptor membrane associated component 1 structure has been explored by X-ray crystallographic analysis. Interestingly, whereas apoprogesterone receptor membrane associated component 1 exists as a monomer, the heme-bound progesterone receptor membrane associated component 1 converts into a stable dimer by forming a unique heme-heme stacking structure, leading to activation of epidermal growth factor receptor signaling and chemoresistance in cancer cells. Furthermore, the gas mediator carbon monoxide inhibits progesterone receptor membrane associated component 1-mediated activation in cancer cells by dissociating the heme-stacking dimer of progesterone receptor membrane associated component 1. The dynamic structural regulation of progesterone receptor membrane associated component 1 will provide new insights for understanding the mechanisms underlying its various functions.

Original languageEnglish
Pages (from-to)12-17
Number of pages6
JournalJournal of Clinical Biochemistry and Nutrition
Volume63
Issue number1
DOIs
Publication statusPublished - 2018 Jul 1

Fingerprint

Progesterone Receptors
Carbon Monoxide
Membrane Proteins
Membranes
Heme
Cells
Neoplasms
Dimers
Chemical activation
Biological Phenomena
Structural dynamics
Epidermal Growth Factor Receptor
Neurons
Tumors
Monomers
Gases
X-Rays
X rays

Keywords

  • Cancer
  • Carbon monoxide
  • Chemoresistance
  • Heme
  • Metabolism
  • Neuron

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

Cite this

Function and structural regulation of the carbon monoxide (CO)-responsive membrane protein PGRMC1. / Kabe, Yasuaki; Handa, Hiroshi; Suematsu, Makoto.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 63, No. 1, 01.07.2018, p. 12-17.

Research output: Contribution to journalReview article

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