Function, molecular structure and gene expression of stem cell factor (SCF)

S. Okada, T. Suda

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Mice of genotype W/Wv and Sl/Sld have been considered as a model of instinct hemopoietic disorders. W/Wv mice have a defect in hemopoietic stem cells and Sl/Sld mice have a defect in the microenvironment. The W locus in murine chromosome 5 encodes the c-kit proto-oncogene and the Sl locus in chromosome 10 encodes the ligand for c-kit, which has been named stem cell factor (SCF), mast cell growth factor (MGF), kit ligand (KL) and steel factor (SL). The cDNA sequence of SCF suggest that it is synthesized as an integral transmembrane protein and that it has common tertiary structure with M-CSF. SCF enhances the proliferation of hemopoietic stem cells and progenitor cells as well as mast cell in combination with other growth factors. Furthermore, it plays an important role in the proliferation and migration of embryonic stem cell, primordial germ cell and melanocyte.

Original languageEnglish
Pages (from-to)1872-1878
Number of pages7
JournalNippon rinsho. Japanese journal of clinical medicine
Volume50
Issue number8
Publication statusPublished - 1992 Aug

ASJC Scopus subject areas

  • Medicine(all)

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