Function of DnaA protein, the initiator for chromosomal DNA replication in E. Coli

Tohru Mizushima

Research output: Contribution to journalReview article

Abstract

DnaA protein is an initiator for chromosomal DNA replication in E. coli. We have examined the function of the protein to answer the following four questions; How DnaA protein is inactivated after DNA replication for the suppression of re-initiation? How DnaA protein is activated for the initiation of DNA replication? Does DnaA protein have functions other than that for DNA replication? Is DnaA protein is a good target for new antibiotics? In this review, I summarize our recent studies for these questions.

Original languageEnglish
Pages (from-to)257-271
Number of pages15
JournalYakugaku Zasshi
Volume118
Issue number7
DOIs
Publication statusPublished - 1998 Jul

Keywords

  • ATPase
  • DNA replication
  • DnaA protein
  • Gene expression
  • Inhibitor
  • Phospholipid

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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