Function of DnaA protein, the initiator for chromosomal DNA replication in E. Coli

Tohru Mizushima

Research output: Contribution to journalReview articlepeer-review

Abstract

DnaA protein is an initiator for chromosomal DNA replication in E. coli. We have examined the function of the protein to answer the following four questions; How DnaA protein is inactivated after DNA replication for the suppression of re-initiation? How DnaA protein is activated for the initiation of DNA replication? Does DnaA protein have functions other than that for DNA replication? Is DnaA protein is a good target for new antibiotics? In this review, I summarize our recent studies for these questions.

Original languageEnglish
Pages (from-to)257-271
Number of pages15
JournalYakugaku Zasshi
Volume118
Issue number7
DOIs
Publication statusPublished - 1998 Jul

Keywords

  • ATPase
  • DNA replication
  • DnaA protein
  • Gene expression
  • Inhibitor
  • Phospholipid

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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