Abstract
Rates of nonsynonymous substitution (dN) significantly higher than rates of synonymous substitution (dS) have been used as evidence of positive selection for the fixation of advantageous point mutations. It has been suggested that positive selection contributes to the evolution of virulence factors and certain functional categories in bacterial pathogens. The genus Streptococcus contains a number of important human and agricultural pathogens. Here we assessed positive selection across 13 Streptococcus species, and their relationship with virulence factors and functional categories. We found that known virulence genes were subject to positive selection pressure as much as other genes. After false discovery rate correction for multiple comparisons, no functional categories were significantly over- or under-represented in positively selected genes relative to other genes. Our results suggest that within the genus Streptococcus positive selection based on dN/dS ratios is not distributed with bias across biological functions.
| Original language | English |
|---|---|
| Pages (from-to) | 274-277 |
| Number of pages | 4 |
| Journal | Infection, Genetics and Evolution |
| Volume | 12 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2012 Mar |
| Externally published | Yes |
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Keywords
- Gene functional categories
- Positive selection
- Streptococcus
- Virulence factor
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Genetics
- Molecular Biology
- Microbiology
- Infectious Diseases
- Microbiology (medical)
Cite this
Functional bias of positively selected genes in Streptococcus genomes. / Suzuki, Haruo; Stanhope, Michael J.
In: Infection, Genetics and Evolution, Vol. 12, No. 2, 03.2012, p. 274-277.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Functional bias of positively selected genes in Streptococcus genomes
AU - Suzuki, Haruo
AU - Stanhope, Michael J.
PY - 2012/3
Y1 - 2012/3
N2 - Rates of nonsynonymous substitution (dN) significantly higher than rates of synonymous substitution (dS) have been used as evidence of positive selection for the fixation of advantageous point mutations. It has been suggested that positive selection contributes to the evolution of virulence factors and certain functional categories in bacterial pathogens. The genus Streptococcus contains a number of important human and agricultural pathogens. Here we assessed positive selection across 13 Streptococcus species, and their relationship with virulence factors and functional categories. We found that known virulence genes were subject to positive selection pressure as much as other genes. After false discovery rate correction for multiple comparisons, no functional categories were significantly over- or under-represented in positively selected genes relative to other genes. Our results suggest that within the genus Streptococcus positive selection based on dN/dS ratios is not distributed with bias across biological functions.
AB - Rates of nonsynonymous substitution (dN) significantly higher than rates of synonymous substitution (dS) have been used as evidence of positive selection for the fixation of advantageous point mutations. It has been suggested that positive selection contributes to the evolution of virulence factors and certain functional categories in bacterial pathogens. The genus Streptococcus contains a number of important human and agricultural pathogens. Here we assessed positive selection across 13 Streptococcus species, and their relationship with virulence factors and functional categories. We found that known virulence genes were subject to positive selection pressure as much as other genes. After false discovery rate correction for multiple comparisons, no functional categories were significantly over- or under-represented in positively selected genes relative to other genes. Our results suggest that within the genus Streptococcus positive selection based on dN/dS ratios is not distributed with bias across biological functions.
KW - Gene functional categories
KW - Positive selection
KW - Streptococcus
KW - Virulence factor
UR - http://www.scopus.com/inward/record.url?scp=84863408547&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863408547&partnerID=8YFLogxK
U2 - 10.1016/j.meegid.2011.11.004
DO - 10.1016/j.meegid.2011.11.004
M3 - Article
C2 - 22155358
AN - SCOPUS:84863408547
VL - 12
SP - 274
EP - 277
JO - Infection, Genetics and Evolution
JF - Infection, Genetics and Evolution
SN - 1567-1348
IS - 2
ER -