Functional lacrimal gland regeneration

Masatoshi Hirayama, Kazuo Tsubota, Takashi Tsuji

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The lacrimal gland is an indispensable organ to secrete tear for maintaining a homeostatic microenvironment for healthy ocular surfaces. The lacrimal gland develops from its organ germ at ocular epithelium via epithelial and mesenchymal interactions into mature secretory gland structure, which consists of acini, ducts, myoepithelial cells, and peripheral tissues such as nerves. Dysfunction of the lacrimal gland leads to dry eye disease, which is one of the prevalent eye disorders involving ocular discomfort, significant visual disturbances, and a reduced quality of life. Current clinical therapies for dry eye disease are artificial tear eye drops, but they are transient and palliative approach. To restore functions of the lacrimal gland, lacrimal tissue stem cells have been identified for regenerative therapeutic approaches. Fully functional organ replacement such as for tooth and hair follicles has also been developed as a novel three-dimensional organ regeneration using stem cell manipulation-named the organ germ method. Recently, we successfully demonstrated fully functional bioengineered lacrimal gland replacements after transplanting a bioengineered organ germ. This study was a significant advance in possible lacrimal gland organ replacement as a next-generation regenerative therapy for dry eye disease. In this review, we summarize recent progress in lacrimal regeneration research and the development of bioengineered lacrimal gland organ replacement therapy.

Original languageEnglish
Title of host publicationOrgan Regeneration Based on Developmental Biology
PublisherSpringer Singapore
Pages135-151
Number of pages17
ISBN (Electronic)9789811037689
ISBN (Print)9789811037665
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Lacrimal Apparatus
Regeneration
Stem cells
Eye Diseases
Tissue
Tears
Ophthalmic Solutions
Ducts
Stem Cells
Artificial Eye
Hair Follicle
Therapeutics
Tooth
Epithelium
Quality of Life
Research

Keywords

  • Bioengineered lacrimal gland
  • Cell manipulation
  • Dry eye disease
  • Lacrimal gland germ
  • Lacrimal glands
  • Organ germ method
  • Organ regeneration
  • Regenerative medicine
  • Tear
  • Transplantation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hirayama, M., Tsubota, K., & Tsuji, T. (2017). Functional lacrimal gland regeneration. In Organ Regeneration Based on Developmental Biology (pp. 135-151). Springer Singapore. https://doi.org/10.1007/978-981-10-3768-9_8

Functional lacrimal gland regeneration. / Hirayama, Masatoshi; Tsubota, Kazuo; Tsuji, Takashi.

Organ Regeneration Based on Developmental Biology. Springer Singapore, 2017. p. 135-151.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hirayama, M, Tsubota, K & Tsuji, T 2017, Functional lacrimal gland regeneration. in Organ Regeneration Based on Developmental Biology. Springer Singapore, pp. 135-151. https://doi.org/10.1007/978-981-10-3768-9_8
Hirayama M, Tsubota K, Tsuji T. Functional lacrimal gland regeneration. In Organ Regeneration Based on Developmental Biology. Springer Singapore. 2017. p. 135-151 https://doi.org/10.1007/978-981-10-3768-9_8
Hirayama, Masatoshi ; Tsubota, Kazuo ; Tsuji, Takashi. / Functional lacrimal gland regeneration. Organ Regeneration Based on Developmental Biology. Springer Singapore, 2017. pp. 135-151
@inbook{f41c68d85e5e41bda25f3be31486fcd2,
title = "Functional lacrimal gland regeneration",
abstract = "The lacrimal gland is an indispensable organ to secrete tear for maintaining a homeostatic microenvironment for healthy ocular surfaces. The lacrimal gland develops from its organ germ at ocular epithelium via epithelial and mesenchymal interactions into mature secretory gland structure, which consists of acini, ducts, myoepithelial cells, and peripheral tissues such as nerves. Dysfunction of the lacrimal gland leads to dry eye disease, which is one of the prevalent eye disorders involving ocular discomfort, significant visual disturbances, and a reduced quality of life. Current clinical therapies for dry eye disease are artificial tear eye drops, but they are transient and palliative approach. To restore functions of the lacrimal gland, lacrimal tissue stem cells have been identified for regenerative therapeutic approaches. Fully functional organ replacement such as for tooth and hair follicles has also been developed as a novel three-dimensional organ regeneration using stem cell manipulation-named the organ germ method. Recently, we successfully demonstrated fully functional bioengineered lacrimal gland replacements after transplanting a bioengineered organ germ. This study was a significant advance in possible lacrimal gland organ replacement as a next-generation regenerative therapy for dry eye disease. In this review, we summarize recent progress in lacrimal regeneration research and the development of bioengineered lacrimal gland organ replacement therapy.",
keywords = "Bioengineered lacrimal gland, Cell manipulation, Dry eye disease, Lacrimal gland germ, Lacrimal glands, Organ germ method, Organ regeneration, Regenerative medicine, Tear, Transplantation",
author = "Masatoshi Hirayama and Kazuo Tsubota and Takashi Tsuji",
year = "2017",
month = "1",
day = "1",
doi = "10.1007/978-981-10-3768-9_8",
language = "English",
isbn = "9789811037665",
pages = "135--151",
booktitle = "Organ Regeneration Based on Developmental Biology",
publisher = "Springer Singapore",

}

TY - CHAP

T1 - Functional lacrimal gland regeneration

AU - Hirayama, Masatoshi

AU - Tsubota, Kazuo

AU - Tsuji, Takashi

PY - 2017/1/1

Y1 - 2017/1/1

N2 - The lacrimal gland is an indispensable organ to secrete tear for maintaining a homeostatic microenvironment for healthy ocular surfaces. The lacrimal gland develops from its organ germ at ocular epithelium via epithelial and mesenchymal interactions into mature secretory gland structure, which consists of acini, ducts, myoepithelial cells, and peripheral tissues such as nerves. Dysfunction of the lacrimal gland leads to dry eye disease, which is one of the prevalent eye disorders involving ocular discomfort, significant visual disturbances, and a reduced quality of life. Current clinical therapies for dry eye disease are artificial tear eye drops, but they are transient and palliative approach. To restore functions of the lacrimal gland, lacrimal tissue stem cells have been identified for regenerative therapeutic approaches. Fully functional organ replacement such as for tooth and hair follicles has also been developed as a novel three-dimensional organ regeneration using stem cell manipulation-named the organ germ method. Recently, we successfully demonstrated fully functional bioengineered lacrimal gland replacements after transplanting a bioengineered organ germ. This study was a significant advance in possible lacrimal gland organ replacement as a next-generation regenerative therapy for dry eye disease. In this review, we summarize recent progress in lacrimal regeneration research and the development of bioengineered lacrimal gland organ replacement therapy.

AB - The lacrimal gland is an indispensable organ to secrete tear for maintaining a homeostatic microenvironment for healthy ocular surfaces. The lacrimal gland develops from its organ germ at ocular epithelium via epithelial and mesenchymal interactions into mature secretory gland structure, which consists of acini, ducts, myoepithelial cells, and peripheral tissues such as nerves. Dysfunction of the lacrimal gland leads to dry eye disease, which is one of the prevalent eye disorders involving ocular discomfort, significant visual disturbances, and a reduced quality of life. Current clinical therapies for dry eye disease are artificial tear eye drops, but they are transient and palliative approach. To restore functions of the lacrimal gland, lacrimal tissue stem cells have been identified for regenerative therapeutic approaches. Fully functional organ replacement such as for tooth and hair follicles has also been developed as a novel three-dimensional organ regeneration using stem cell manipulation-named the organ germ method. Recently, we successfully demonstrated fully functional bioengineered lacrimal gland replacements after transplanting a bioengineered organ germ. This study was a significant advance in possible lacrimal gland organ replacement as a next-generation regenerative therapy for dry eye disease. In this review, we summarize recent progress in lacrimal regeneration research and the development of bioengineered lacrimal gland organ replacement therapy.

KW - Bioengineered lacrimal gland

KW - Cell manipulation

KW - Dry eye disease

KW - Lacrimal gland germ

KW - Lacrimal glands

KW - Organ germ method

KW - Organ regeneration

KW - Regenerative medicine

KW - Tear

KW - Transplantation

UR - http://www.scopus.com/inward/record.url?scp=85028799576&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028799576&partnerID=8YFLogxK

U2 - 10.1007/978-981-10-3768-9_8

DO - 10.1007/978-981-10-3768-9_8

M3 - Chapter

AN - SCOPUS:85028799576

SN - 9789811037665

SP - 135

EP - 151

BT - Organ Regeneration Based on Developmental Biology

PB - Springer Singapore

ER -