Functionalization of hollow nanoparticles fabricated by the layer-by-layer deposition

Tomonori Toyoda; Keiji Fujimoto

Functionalization of hollow nanoparticles fabricated by the layer-by-layer deposition

Department of Applied Chemistry

Research output: Contribution to conference › Paper › peer-review

Abstract

We prepared hollow particles in nano size using a layer-by-layer deposition. Liposomes were used as a template for the layer-by-layer deposition. At first, negatively charged liposomes were prepared from dilauroyl phosphatidic acid (DLPA) and dimyristoyl phosphatidylcholine (DMPC). Poly-L-lysine (P_Lys) and poly-L-aspartic acid (P_Asp) were used as adsorbates. When the alternative adsorption of P_Lys and P_Asp on the liposomes was repeated for thickening the capsule layer, their ζ-potentials changed between positive and negative charges at each deposition. To investigate the release from liposomes and liposome-polypeptide complex, 1-hydroxypyrene-3,6,8-trisulfonic acid (HPTS) was incorporated. From the leakage experiment in a buffered solution, we found that the adsorption of polymers was related to the release from hollow particles, and the leakage was completely inhibited by the deposition above 400ppm of P_Lys.

Original language	English
Number of pages	1
Publication status	Published - 2005 Dec 1
Event	54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: 2005 May 25 → 2005 May 27

Other

Other	54th SPSJ Annual Meeting 2005
Country/Territory	Japan
City	Yokohama
Period	05/5/25 → 05/5/27

Keywords

Hollow particle
Layer-by-Layer
Nanoparticle

ASJC Scopus subject areas

Engineering(all)

Cite this

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title = "Functionalization of hollow nanoparticles fabricated by the layer-by-layer deposition",

abstract = "We prepared hollow particles in nano size using a layer-by-layer deposition. Liposomes were used as a template for the layer-by-layer deposition. At first, negatively charged liposomes were prepared from dilauroyl phosphatidic acid (DLPA) and dimyristoyl phosphatidylcholine (DMPC). Poly-L-lysine (PLys) and poly-L-aspartic acid (PAsp) were used as adsorbates. When the alternative adsorption of PLys and PAsp on the liposomes was repeated for thickening the capsule layer, their ζ-potentials changed between positive and negative charges at each deposition. To investigate the release from liposomes and liposome-polypeptide complex, 1-hydroxypyrene-3,6,8-trisulfonic acid (HPTS) was incorporated. From the leakage experiment in a buffered solution, we found that the adsorption of polymers was related to the release from hollow particles, and the leakage was completely inhibited by the deposition above 400ppm of PLys.",

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T1 - Functionalization of hollow nanoparticles fabricated by the layer-by-layer deposition

AU - Toyoda, Tomonori

AU - Fujimoto, Keiji

PY - 2005/12/1

Y1 - 2005/12/1

N2 - We prepared hollow particles in nano size using a layer-by-layer deposition. Liposomes were used as a template for the layer-by-layer deposition. At first, negatively charged liposomes were prepared from dilauroyl phosphatidic acid (DLPA) and dimyristoyl phosphatidylcholine (DMPC). Poly-L-lysine (PLys) and poly-L-aspartic acid (PAsp) were used as adsorbates. When the alternative adsorption of PLys and PAsp on the liposomes was repeated for thickening the capsule layer, their ζ-potentials changed between positive and negative charges at each deposition. To investigate the release from liposomes and liposome-polypeptide complex, 1-hydroxypyrene-3,6,8-trisulfonic acid (HPTS) was incorporated. From the leakage experiment in a buffered solution, we found that the adsorption of polymers was related to the release from hollow particles, and the leakage was completely inhibited by the deposition above 400ppm of PLys.

AB - We prepared hollow particles in nano size using a layer-by-layer deposition. Liposomes were used as a template for the layer-by-layer deposition. At first, negatively charged liposomes were prepared from dilauroyl phosphatidic acid (DLPA) and dimyristoyl phosphatidylcholine (DMPC). Poly-L-lysine (PLys) and poly-L-aspartic acid (PAsp) were used as adsorbates. When the alternative adsorption of PLys and PAsp on the liposomes was repeated for thickening the capsule layer, their ζ-potentials changed between positive and negative charges at each deposition. To investigate the release from liposomes and liposome-polypeptide complex, 1-hydroxypyrene-3,6,8-trisulfonic acid (HPTS) was incorporated. From the leakage experiment in a buffered solution, we found that the adsorption of polymers was related to the release from hollow particles, and the leakage was completely inhibited by the deposition above 400ppm of PLys.

KW - Hollow particle

KW - Layer-by-Layer

KW - Nanoparticle

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T2 - 54th SPSJ Annual Meeting 2005

Y2 - 25 May 2005 through 27 May 2005

ER -

Functionalization of hollow nanoparticles fabricated by the layer-by-layer deposition

Abstract

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Keywords

ASJC Scopus subject areas

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