Functionalized core-shell hydrogel microsprings by anisotropic gelation with bevel-tip capillary

Koki Yoshida, Hiroaki Onoe

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This study describes a novel microfluidic-based method for the synthesis of hydrogel microsprings that are capable of encapsulating various functional materials. A continuous flow of alginate pre-gel solution can spontaneously form a hydrogel microspring by anisotropic gelation around the bevel-tip of the capillary. This technique allows fabrication of hydrogel microsprings using only simple capillaries and syringe pumps, while their complex compartmentalization characterized by a laminar flow inside the capillary can contribute to the optimization of the microspring internal structure and functionality. Encapsulation of several functional materials including magnetic-responsive nanoparticles or cell dispersed collagen for tissue scaffold was demonstrated to functionalize the microsprings. Our core-shell hydrogel microsprings have immense potential for application in a number of fields, including biological/chemical microsensors, biocompatible soft robots/microactuators, drug release, self-assembly of 3D structures and tissue engineering.

Original languageEnglish
Article number45987
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 2017 Apr 5

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Hydrogel
Gelation
Functional materials
Tissue Scaffolds
Microactuators
Syringes
Microsensors
Laminar flow
Encapsulation
Tissue engineering
Microfluidics
Self assembly
Collagen
Gels
Pumps
Robots
Nanoparticles
Fabrication
Pharmaceutical Preparations

ASJC Scopus subject areas

  • General

Cite this

Functionalized core-shell hydrogel microsprings by anisotropic gelation with bevel-tip capillary. / Yoshida, Koki; Onoe, Hiroaki.

In: Scientific Reports, Vol. 7, 45987, 05.04.2017.

Research output: Contribution to journalArticle

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