Functions and regulation of lipocalin-2 in gut-origin sepsis: A narrative review

Research output: Contribution to journalReview article

Abstract

Lipocalin-2 (Lcn2), an innate immune protein, has come to be recognized for its roles in iron homeostasis, infection, and inflammation. In this narrative review, we provide a comprehensive description based on currently available evidence of the clinical implications of Lcn2 and its therapeutic potency in gut-origin sepsis. Lcn2 appears to mitigate gut barrier injury via maintaining homeostasis of the microbiota and exerting antioxidant strategy, as well as by deactivating macrophages and inducing immune cell apoptosis to terminate systemic hyper-inflammation. We propose that development of a therapeutic strategy targeting lipocalin-2 could be highly promising in the management of gut-origin sepsis.

Original languageEnglish
Article number269
JournalCritical Care
Volume23
Issue number1
DOIs
Publication statusPublished - 2019 Aug 2

Fingerprint

Sepsis
Homeostasis
Inflammation
Microbiota
Iron
Antioxidants
Macrophages
Apoptosis
Lipocalin-2
Wounds and Injuries
Therapeutics
Infection
Proteins

Keywords

  • Gastrointestinal microbiome
  • Inflammation
  • Lipocalin-2
  • Macrophages
  • Neutrophils
  • Sepsis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Functions and regulation of lipocalin-2 in gut-origin sepsis : A narrative review. / Lu, Fanglin; Inoue, Kei; Kato, Jungo; Minamishima, Shizuka; Morisaki, Hiroshi.

In: Critical Care, Vol. 23, No. 1, 269, 02.08.2019.

Research output: Contribution to journalReview article

@article{abb8baffa4d74810a5e0000b8920f0d0,
title = "Functions and regulation of lipocalin-2 in gut-origin sepsis: A narrative review",
abstract = "Lipocalin-2 (Lcn2), an innate immune protein, has come to be recognized for its roles in iron homeostasis, infection, and inflammation. In this narrative review, we provide a comprehensive description based on currently available evidence of the clinical implications of Lcn2 and its therapeutic potency in gut-origin sepsis. Lcn2 appears to mitigate gut barrier injury via maintaining homeostasis of the microbiota and exerting antioxidant strategy, as well as by deactivating macrophages and inducing immune cell apoptosis to terminate systemic hyper-inflammation. We propose that development of a therapeutic strategy targeting lipocalin-2 could be highly promising in the management of gut-origin sepsis.",
keywords = "Gastrointestinal microbiome, Inflammation, Lipocalin-2, Macrophages, Neutrophils, Sepsis",
author = "Fanglin Lu and Kei Inoue and Jungo Kato and Shizuka Minamishima and Hiroshi Morisaki",
year = "2019",
month = "8",
day = "2",
doi = "10.1186/s13054-019-2550-2",
language = "English",
volume = "23",
journal = "Critical Care",
issn = "1364-8535",
publisher = "BioMed Central Ltd.",
number = "1",

}

TY - JOUR

T1 - Functions and regulation of lipocalin-2 in gut-origin sepsis

T2 - A narrative review

AU - Lu, Fanglin

AU - Inoue, Kei

AU - Kato, Jungo

AU - Minamishima, Shizuka

AU - Morisaki, Hiroshi

PY - 2019/8/2

Y1 - 2019/8/2

N2 - Lipocalin-2 (Lcn2), an innate immune protein, has come to be recognized for its roles in iron homeostasis, infection, and inflammation. In this narrative review, we provide a comprehensive description based on currently available evidence of the clinical implications of Lcn2 and its therapeutic potency in gut-origin sepsis. Lcn2 appears to mitigate gut barrier injury via maintaining homeostasis of the microbiota and exerting antioxidant strategy, as well as by deactivating macrophages and inducing immune cell apoptosis to terminate systemic hyper-inflammation. We propose that development of a therapeutic strategy targeting lipocalin-2 could be highly promising in the management of gut-origin sepsis.

AB - Lipocalin-2 (Lcn2), an innate immune protein, has come to be recognized for its roles in iron homeostasis, infection, and inflammation. In this narrative review, we provide a comprehensive description based on currently available evidence of the clinical implications of Lcn2 and its therapeutic potency in gut-origin sepsis. Lcn2 appears to mitigate gut barrier injury via maintaining homeostasis of the microbiota and exerting antioxidant strategy, as well as by deactivating macrophages and inducing immune cell apoptosis to terminate systemic hyper-inflammation. We propose that development of a therapeutic strategy targeting lipocalin-2 could be highly promising in the management of gut-origin sepsis.

KW - Gastrointestinal microbiome

KW - Inflammation

KW - Lipocalin-2

KW - Macrophages

KW - Neutrophils

KW - Sepsis

UR - http://www.scopus.com/inward/record.url?scp=85070234663&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070234663&partnerID=8YFLogxK

U2 - 10.1186/s13054-019-2550-2

DO - 10.1186/s13054-019-2550-2

M3 - Review article

C2 - 31375129

AN - SCOPUS:85070234663

VL - 23

JO - Critical Care

JF - Critical Care

SN - 1364-8535

IS - 1

M1 - 269

ER -