TY - JOUR
T1 - Fundamental and clinical evaluation of a new orally administrable cephalosporin, cefaclor in pediatric field
AU - Akita, Hironobu
AU - Hotta, Masahiro
AU - Yamashita, Naoya
AU - Nanri, Seiichiro
AU - Sunakawa, Keisuke
AU - Hara, Noriyoshi
AU - Kojima, Yoshibumi
AU - Osano, Mitsuru
AU - Ichihashi, Yasuo
AU - Kori, Takeo
AU - Iwata, Satoshi
AU - Sakamoto, Mari
AU - Sato, Yoshitake
PY - 1979/1/1
Y1 - 1979/1/1
N2 - Cefaclor, a new orally administrable cephalosporin, was evaluated fundamentally and clinically in children and following results were obtained. (1) Serum levels of orally administered cefaclor were measured and, revealed a prompt rise and fall with a half life of 20∼50 minutes. Maximal serum level was obtained 30 minutes after administration and was 16.5 μg/ml by a single oral dose of 25 mg/kg of body weight. Following serum concentrations of cefaclor were one hour, 11.2 μg/ml, 2 hours, 2.27μg/ml, 4 hours, 0.77 μg/ml and 6 hours, 0.2 μg/ml respectively. (2) Maximal serum concentration was lower than that of cephalexin (CEX). This might be the result of relative unstability of cefaclor compared with CEX. (3) Clinical evaluation was done in 31 cases, consisting of 18 cases in upper respiratory infection, 8 cases in bronchitis and bronchopneumonia, 3 cases in urinary tract infection and 2 other cases. The results of 29 out of 31 cases were excellent and good clinically. (4) Among 16 cases, in which pathological microorganisms were isolated from their throat or urine, 14 cases (88%) revealed good responses bacteriologically. (5) According to these results, it was suggested that cefaclor is more effective on respiratory and urinary tract infections with lesser side effects than CEX is, and useful in pediatric field.
AB - Cefaclor, a new orally administrable cephalosporin, was evaluated fundamentally and clinically in children and following results were obtained. (1) Serum levels of orally administered cefaclor were measured and, revealed a prompt rise and fall with a half life of 20∼50 minutes. Maximal serum level was obtained 30 minutes after administration and was 16.5 μg/ml by a single oral dose of 25 mg/kg of body weight. Following serum concentrations of cefaclor were one hour, 11.2 μg/ml, 2 hours, 2.27μg/ml, 4 hours, 0.77 μg/ml and 6 hours, 0.2 μg/ml respectively. (2) Maximal serum concentration was lower than that of cephalexin (CEX). This might be the result of relative unstability of cefaclor compared with CEX. (3) Clinical evaluation was done in 31 cases, consisting of 18 cases in upper respiratory infection, 8 cases in bronchitis and bronchopneumonia, 3 cases in urinary tract infection and 2 other cases. The results of 29 out of 31 cases were excellent and good clinically. (4) Among 16 cases, in which pathological microorganisms were isolated from their throat or urine, 14 cases (88%) revealed good responses bacteriologically. (5) According to these results, it was suggested that cefaclor is more effective on respiratory and urinary tract infections with lesser side effects than CEX is, and useful in pediatric field.
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U2 - 10.11250/chemotherapy1953.27.Supplement7_355
DO - 10.11250/chemotherapy1953.27.Supplement7_355
M3 - Article
AN - SCOPUS:0018574361
SN - 0009-3165
VL - 27
SP - 355
EP - 361
JO - CHEMOTHERAPY
JF - CHEMOTHERAPY
ER -
