Fundamental and clinical evaluation of ceftazidime in neonates and premature infants

Y. Sato, S. Iwata, Y. Kusumoto, H. Shiro, T. Oikawa, M. Osano

Research output: Contribution to journalArticle

Abstract

Fundamental and clinical evaluation of ceftazidime (CAZ) were carried out in neonates and premature infants. 1. Serum concentrations of CAZ after administration of 20 mg/kg were satisfactorily high regardless of the route of administration: bolus intravenous injection or 1-hour intravenous drip infusion. Like other cephem antibiotics, half-lives tended to be shorter as the ages of subjects became higher. 2. Although there were some differences in urinary recovery rates between different dosage groups, they were generally high. 3. Clinical efficacy was either excellent or good in all 21 assessable cases. 4. In 23 cases examined for adverse effects, diarrhea was observed in 1 case, and elevation of GOT and GPT, in another case.

Original languageEnglish
Pages (from-to)2084-2096
Number of pages13
JournalJapanese Journal of Antibiotics
Volume39
Issue number8
Publication statusPublished - 1986

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Ceftazidime
Intravenous Infusions
Premature Infants
Newborn Infant
Intravenous Injections
Diarrhea
Anti-Bacterial Agents
Serum

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Sato, Y., Iwata, S., Kusumoto, Y., Shiro, H., Oikawa, T., & Osano, M. (1986). Fundamental and clinical evaluation of ceftazidime in neonates and premature infants. Japanese Journal of Antibiotics, 39(8), 2084-2096.

Fundamental and clinical evaluation of ceftazidime in neonates and premature infants. / Sato, Y.; Iwata, S.; Kusumoto, Y.; Shiro, H.; Oikawa, T.; Osano, M.

In: Japanese Journal of Antibiotics, Vol. 39, No. 8, 1986, p. 2084-2096.

Research output: Contribution to journalArticle

Sato, Y, Iwata, S, Kusumoto, Y, Shiro, H, Oikawa, T & Osano, M 1986, 'Fundamental and clinical evaluation of ceftazidime in neonates and premature infants', Japanese Journal of Antibiotics, vol. 39, no. 8, pp. 2084-2096.
Sato Y, Iwata S, Kusumoto Y, Shiro H, Oikawa T, Osano M. Fundamental and clinical evaluation of ceftazidime in neonates and premature infants. Japanese Journal of Antibiotics. 1986;39(8):2084-2096.
Sato, Y. ; Iwata, S. ; Kusumoto, Y. ; Shiro, H. ; Oikawa, T. ; Osano, M. / Fundamental and clinical evaluation of ceftazidime in neonates and premature infants. In: Japanese Journal of Antibiotics. 1986 ; Vol. 39, No. 8. pp. 2084-2096.
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