Fundamental and clinical evaluations on ceftriaxone in neonates

K. Sunakawa, Y. Ishizuka, N. Saito, N. Kawai, H. Akita, S. Iwata, Y. Sato

Research output: Contribution to journalArticle

Abstract

The antibacterial efficacy of ceftriaxone (CTRX) against group B Streptococcus and its clinical efficacy in newborns were examined, and the results obtained are summarized as follows. 1. MIC's of CTRX against 55 strains of B group Streptococcus from the pregnant vagina were 0.10 μg/ml or lower. 2. Efficacies of CTRX were good to excellent in 8 cases administered for treatment, 3 cases for prophylaxis and 1 for observation of adverse reactions. Observed adverse reactions included diarrhea in 4 cases and vomiting in 2 cases. As abnormal laboratory parameters, eosinophilia and thrombocytosis were observed in 1 case each. 3. An examination of intestinal bacteria in 9 cases revealed that CTRX gave as much influence to the flora as other third-generation cephems. 4. An examination for the vitamin K deficiency in 11 cases found a prolongation of prothrombin time (PT) in 3 cases and protein induced by vitamin K absence (PIVKA) II positive in 2 cases. 5. Testing of platelet aggregation with adenosine diphosphate (ADP) in 7 cases showed little influence of CTRX.

Original languageEnglish
Pages (from-to)133-143
Number of pages11
JournalJapanese Journal of Antibiotics
Volume41
Issue number2
Publication statusPublished - 1988

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Ceftriaxone
Streptococcus agalactiae
Vitamin K Deficiency
Thrombocytosis
Vitamin K
Prothrombin Time
Eosinophilia
Vagina
Platelet Aggregation
Adenosine Diphosphate
Vomiting
Diarrhea
Observation
Bacteria
Proteins

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Sunakawa, K., Ishizuka, Y., Saito, N., Kawai, N., Akita, H., Iwata, S., & Sato, Y. (1988). Fundamental and clinical evaluations on ceftriaxone in neonates. Japanese Journal of Antibiotics, 41(2), 133-143.

Fundamental and clinical evaluations on ceftriaxone in neonates. / Sunakawa, K.; Ishizuka, Y.; Saito, N.; Kawai, N.; Akita, H.; Iwata, S.; Sato, Y.

In: Japanese Journal of Antibiotics, Vol. 41, No. 2, 1988, p. 133-143.

Research output: Contribution to journalArticle

Sunakawa, K, Ishizuka, Y, Saito, N, Kawai, N, Akita, H, Iwata, S & Sato, Y 1988, 'Fundamental and clinical evaluations on ceftriaxone in neonates', Japanese Journal of Antibiotics, vol. 41, no. 2, pp. 133-143.
Sunakawa K, Ishizuka Y, Saito N, Kawai N, Akita H, Iwata S et al. Fundamental and clinical evaluations on ceftriaxone in neonates. Japanese Journal of Antibiotics. 1988;41(2):133-143.
Sunakawa, K. ; Ishizuka, Y. ; Saito, N. ; Kawai, N. ; Akita, H. ; Iwata, S. ; Sato, Y. / Fundamental and clinical evaluations on ceftriaxone in neonates. In: Japanese Journal of Antibiotics. 1988 ; Vol. 41, No. 2. pp. 133-143.
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