TY - JOUR
T1 - Fundamental and clinical studies of cefotiam in the field of pediatrics
AU - Akita, Hironobu
AU - Iwasaki, Yukio
AU - Iwata, Satoshi
AU - Kanemitsu, Takafumi
AU - Hattori, Haruki
AU - Jozaki, Keiji
AU - Hotta, Masahiro
AU - Yamashita, Naoya
AU - Nanri, Seiichiro
AU - Kojima, Yoshibumi
AU - Hara, Noriyoshi
AU - Sunagawa, Keisuke
AU - Oikawa, Tadao
AU - Iwata, Takashi
AU - Osano, Mitsuru
AU - Ichihashi, Yasuo
PY - 1981/1/1
Y1 - 1981/1/1
N2 - The fundamental and clinical studies on cefotiam (CTM) were performed in the field of pediatrics, and the following results were obtained: 1. The peak MICs of CTM against Gram negative rods such as E. coli, Klebsiella, Salmonella, Proteus were 1.56mcg/ml. The MIC distribution against S. aureus was almost equal to the conventional cephalosporin antibiotics. The MICs against P. seudomonas and Serratia were over 400mcg/ml. 2. The mean serum levels of CTM after bolus intravenous injection of 25mg/kg were 59.9mg/ml after 15 min., 30.0mcg/ml after 30min., 15.6mcg/ml after 1 hour. 3. Administration of CTM to 6 pediatric patients produced the clinical responses which were good in all 6 cases and the bacterial effects of eradication in 3 cases and superinfection in the 2 cases in the 5 cases from whom the organism were isolated. No side effect was observed. From the above results, it is considered that a bolus injection of CTM 25 mg/kg t. i. d. to q. i. d. is a safe and useful treatment for pediatric cases.
AB - The fundamental and clinical studies on cefotiam (CTM) were performed in the field of pediatrics, and the following results were obtained: 1. The peak MICs of CTM against Gram negative rods such as E. coli, Klebsiella, Salmonella, Proteus were 1.56mcg/ml. The MIC distribution against S. aureus was almost equal to the conventional cephalosporin antibiotics. The MICs against P. seudomonas and Serratia were over 400mcg/ml. 2. The mean serum levels of CTM after bolus intravenous injection of 25mg/kg were 59.9mg/ml after 15 min., 30.0mcg/ml after 30min., 15.6mcg/ml after 1 hour. 3. Administration of CTM to 6 pediatric patients produced the clinical responses which were good in all 6 cases and the bacterial effects of eradication in 3 cases and superinfection in the 2 cases in the 5 cases from whom the organism were isolated. No side effect was observed. From the above results, it is considered that a bolus injection of CTM 25 mg/kg t. i. d. to q. i. d. is a safe and useful treatment for pediatric cases.
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U2 - 10.11553/antibiotics1968b.34.723
DO - 10.11553/antibiotics1968b.34.723
M3 - Article
C2 - 6270415
AN - SCOPUS:0019439483
VL - 34
SP - 723
EP - 728
JO - The Journal of antibiotics. Ser. B
JF - The Journal of antibiotics. Ser. B
SN - 0368-2781
IS - 5
ER -
