Fundamental and clinical studies on ampicillin suppository (ks-r1) in the fieldof pediatrics

Keiji Jozaki, Satoshi Iwata, Yukio Iwasaki, Yoshitake Sato, Ryoh Wakabayashi, Sinya Hayano, Keisuke Sunagawa, Mitsuru Osano

Research output: Contribution to journalArticle

Abstract

1. Blood levels of ampicillin (ABPC) were measured in 10 childrish patients with heart disease after the rectal administration of KS-R1 at doses of 125 mg and 250 mg. Average blood levels of ABPC at 15, 30 minutes, 1,2 hours and 4 hours after the administration of KS-R1 were 6.8, 6.9,3.1, 1.1 mcg/ml and 0.1 mcg/ml with half-life of 0.64 hours in patients of age from 1 year to 4 years 7 months old (dose level 8.9 ~ 13.9 mg/kg, average 10.5 mg/kg), and 5.2, 6.1, 3.4, 1.0 mcg/ml and 0.1 mcg/ml with half-life of 0.65 hours in patients of age from 7 years 10 months to 10 years 7 months old (dose level 8.3 ~ 13.9 mg/kg, average 9.8 mg/kg), respectively. 2. Clinical effective rate (excellent and good) was %1% in 55 childish patients with infections. 3. Bacteriologically, 13 strains {14%) out of 18 strains which were isolated from the patients were eradicated. 4. No severe side effects were observed. Diarrhea was observed in 3 cases.

Original languageEnglish
Pages (from-to)1806-1813
Number of pages8
Journalthe japanese journal of antibiotics
Volume36
Issue number7
DOIs
Publication statusPublished - 1983 Jan 1

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Fundamental and clinical studies on ampicillin suppository (ks-r1) in the fieldof pediatrics'. Together they form a unique fingerprint.

  • Cite this

    Jozaki, K., Iwata, S., Iwasaki, Y., Sato, Y., Wakabayashi, R., Hayano, S., Sunagawa, K., & Osano, M. (1983). Fundamental and clinical studies on ampicillin suppository (ks-r1) in the fieldof pediatrics. the japanese journal of antibiotics, 36(7), 1806-1813. https://doi.org/10.11553/antibiotics1968b.36.1806