Fundamental and clinical results of AZT in pediatrics were as follows. 1. Pharmacokinetics of AZT was studied for 1 case with resulting high serum concentration and a halflife of approximate 1 hour. 2. AZT was administered to 10 patients with bacterial infections with 100% clinical efficacy and 62.5% bacterial elimination. Side effect was 1 case of diarrhea. 3. There were no abnormal laboratory or coagulation test findings nor vitamin K deficiency, platelet hypofunction or effects on intestinal bacterial flora. AZT was considered to be high in safety. 4. The administration of 20 mg/kg AZT 3 times a day was considered to be an effective treatment for pediatric Gram-negative infections.
|Number of pages||9|
|Journal||the japanese journal of antibiotics|
|Publication status||Published - 1985|
ASJC Scopus subject areas
- Microbiology (medical)
- Pharmacology (medical)
- Infectious Diseases