Fundamental and Clinical Studies on Aztreonam in Pediatrics

Keisuke Sunakawa, Nobuo Saito, Yugo Ishizuka, Satoshi Iwata, Yoshitake Sato, Hironobu Akita

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Fundamental and clinical results of AZT in pediatrics were as follows. 1. Pharmacokinetics of AZT was studied for 1 case with resulting high serum concentration and a halflife of approximate 1 hour. 2. AZT was administered to 10 patients with bacterial infections with 100% clinical efficacy and 62.5% bacterial elimination. Side effect was 1 case of diarrhea. 3. There were no abnormal laboratory or coagulation test findings nor vitamin K deficiency, platelet hypofunction or effects on intestinal bacterial flora. AZT was considered to be high in safety. 4. The administration of 20 mg/kg AZT 3 times a day was considered to be an effective treatment for pediatric Gram-negative infections.

Original languageEnglish
Pages (from-to)3230-3238
Number of pages9
Journalthe japanese journal of antibiotics
Volume38
Issue number11
DOIs
Publication statusPublished - 1985 Jan 1

    Fingerprint

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Sunakawa, K., Saito, N., Ishizuka, Y., Iwata, S., Sato, Y., & Akita, H. (1985). Fundamental and Clinical Studies on Aztreonam in Pediatrics. the japanese journal of antibiotics, 38(11), 3230-3238. https://doi.org/10.11553/antibiotics1968b.38.3230