Fungemia due to Rhodotorula mucilaginosa after allogeneic hematopoietic stem cell transplantation

Takehiko Mori, Y. Nakamura, Jun Kato, K. Sugita, Mitsuru Murata, K. Kamei, Shinichiro Okamoto

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Rhodotorula species have been increasingly recognized as emerging pathogens, particularly in immunocompromised patients. We herein report on a patient with myelodysplastic syndrome who developed fungemia due to Rhodotorula mucilaginosa after allogeneic hematopoietic stem cell transplantation (HSCT) from an unrelated donor. He developed severe acute graft-versus-host disease requiring high-dose steroids, and had serially been administered fluconazole and micafungin for the prophylaxis of fungal infection. Although several cases of Rhodotorula infection after HSCT have been reported, all of them were recipients of autologous HSCT, not allogeneic HSCT. A review of all the reported cases of Rhodotorula infection after HSCT revealed that all patients had received fluconazole or echinocandins before the onset of infection. The findings suggest that Rhodotorula species could be causative yeasts, particularly in patients receiving fluconazole or echinocandins, both of which are inactive against the species.

Original languageEnglish
Pages (from-to)91-94
Number of pages4
JournalTransplant Infectious Disease
Volume14
Issue number1
DOIs
Publication statusPublished - 2012 Feb

Fingerprint

Fungemia
Rhodotorula
Hematopoietic Stem Cell Transplantation
Fluconazole
Echinocandins
Infection
Unrelated Donors
Mycoses
Myelodysplastic Syndromes
Immunocompromised Host
Graft vs Host Disease
Yeasts
Steroids

Keywords

  • Allogeneic hematopoietic stem cell transplantation
  • Central line
  • Fungemia
  • Myelodysplastic syndrome
  • Rhodotorula mucilaginosa

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

Fungemia due to Rhodotorula mucilaginosa after allogeneic hematopoietic stem cell transplantation. / Mori, Takehiko; Nakamura, Y.; Kato, Jun; Sugita, K.; Murata, Mitsuru; Kamei, K.; Okamoto, Shinichiro.

In: Transplant Infectious Disease, Vol. 14, No. 1, 02.2012, p. 91-94.

Research output: Contribution to journalArticle

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