Fusion Genes in Cancer-Toward Treatment from a Pan-Cancer Perspective

Shigenari Nukaga, Takashi Kohno

Research output: Contribution to journalReview articlepeer-review


In recent years, genetic testing using next-generation sequencers has become widespread in the field of cancer drug therapy, and treatments based on individual genetic disorders are now routinely used. Drug development is underway to target various fusion genes among the detected genetic disorders. However, the functional significance of most of the detected fusion genes is unknown, and it is necessary to understand their biological characteristics and elucidate their functions for the development of personalized medicine. We review the molecular biology, detection, and treatment of cancer fusion genes from a pan-cancer perspective.

Original languageEnglish
Pages (from-to)1030-1034
Number of pages5
JournalGan to kagaku ryoho. Cancer & chemotherapy
Issue number10
Publication statusPublished - 2022 Oct 1
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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