Abstract
The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is the major endothelial scavenger receptor against oxidized low-density lipoprotein (Ox-LDL), which has been implicated in the pathogenesis of atherosclerosis. We investigated the G501C mutation in the OLR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 274 age- and sex-matched healthy controls using single nucleotide primer extension analysis (SNuPe). There was no significant difference in the polymorphism between patients with ischemic CVD and controls (GC + CC versus GG, p = 0.48). The C allele was not significantly different between the patients and controls (C versus G, p = 0.91). Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population.
| Original language | English |
|---|---|
| Pages (from-to) | 246-249 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 1121 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2006 Nov 22 |
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Keywords
- Atherosclerosis
- Ischemic stroke
- Oxidized LDL
- Oxidized low-density lipoprotein receptor 1
- Polymorphism
- Single nucleotide primer extension
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
- Developmental Biology
- Molecular Biology
Cite this
G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke. / Hattori, Hidenori; Sonoda, Akira; Sato, Hideki; Ito, Daisuke; Tanahashi, Norio; Murata, Mitsuru; Saito, Ikuo; Watanabe, Kiyoaki; Suzuki, Norihiro.
In: Brain Research, Vol. 1121, No. 1, 22.11.2006, p. 246-249.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke
AU - Hattori, Hidenori
AU - Sonoda, Akira
AU - Sato, Hideki
AU - Ito, Daisuke
AU - Tanahashi, Norio
AU - Murata, Mitsuru
AU - Saito, Ikuo
AU - Watanabe, Kiyoaki
AU - Suzuki, Norihiro
PY - 2006/11/22
Y1 - 2006/11/22
N2 - The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is the major endothelial scavenger receptor against oxidized low-density lipoprotein (Ox-LDL), which has been implicated in the pathogenesis of atherosclerosis. We investigated the G501C mutation in the OLR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 274 age- and sex-matched healthy controls using single nucleotide primer extension analysis (SNuPe). There was no significant difference in the polymorphism between patients with ischemic CVD and controls (GC + CC versus GG, p = 0.48). The C allele was not significantly different between the patients and controls (C versus G, p = 0.91). Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population.
AB - The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is the major endothelial scavenger receptor against oxidized low-density lipoprotein (Ox-LDL), which has been implicated in the pathogenesis of atherosclerosis. We investigated the G501C mutation in the OLR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 274 age- and sex-matched healthy controls using single nucleotide primer extension analysis (SNuPe). There was no significant difference in the polymorphism between patients with ischemic CVD and controls (GC + CC versus GG, p = 0.48). The C allele was not significantly different between the patients and controls (C versus G, p = 0.91). Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population.
KW - Atherosclerosis
KW - Ischemic stroke
KW - Oxidized LDL
KW - Oxidized low-density lipoprotein receptor 1
KW - Polymorphism
KW - Single nucleotide primer extension
UR - http://www.scopus.com/inward/record.url?scp=33750706221&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750706221&partnerID=8YFLogxK
U2 - 10.1016/j.brainres.2006.08.091
DO - 10.1016/j.brainres.2006.08.091
M3 - Article
C2 - 17022953
AN - SCOPUS:33750706221
VL - 1121
SP - 246
EP - 249
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -