G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke

Hidenori Hattori, Akira Sonoda, Hideki Sato, Daisuke Ito, Norio Tanahashi, Mitsuru Murata, Ikuo Saito, Kiyoaki Watanabe, Norihiro Suzuki

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22 Citations (Scopus)

Abstract

The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is the major endothelial scavenger receptor against oxidized low-density lipoprotein (Ox-LDL), which has been implicated in the pathogenesis of atherosclerosis. We investigated the G501C mutation in the OLR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 274 age- and sex-matched healthy controls using single nucleotide primer extension analysis (SNuPe). There was no significant difference in the polymorphism between patients with ischemic CVD and controls (GC + CC versus GG, p = 0.48). The C allele was not significantly different between the patients and controls (C versus G, p = 0.91). Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population.

Original languageEnglish
Pages (from-to)246-249
Number of pages4
JournalBrain Research
Volume1121
Issue number1
DOIs
Publication statusPublished - 2006 Nov 22

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Keywords

  • Atherosclerosis
  • Ischemic stroke
  • Oxidized LDL
  • Oxidized low-density lipoprotein receptor 1
  • Polymorphism
  • Single nucleotide primer extension

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Hattori, H., Sonoda, A., Sato, H., Ito, D., Tanahashi, N., Murata, M., Saito, I., Watanabe, K., & Suzuki, N. (2006). G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke. Brain Research, 1121(1), 246-249. https://doi.org/10.1016/j.brainres.2006.08.091