TY - JOUR
T1 - G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke
AU - Hattori, Hidenori
AU - Sonoda, Akira
AU - Sato, Hideki
AU - Ito, Daisuke
AU - Tanahashi, Norio
AU - Murata, Mitsuru
AU - Saito, Ikuo
AU - Watanabe, Kiyoaki
AU - Suzuki, Norihiro
N1 - Funding Information:
This work was supported by a grant-in-aid for scientific research no. H13-genome-006 from the Ministry of Health, Labor and Welfare of Japan.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/11/22
Y1 - 2006/11/22
N2 - The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is the major endothelial scavenger receptor against oxidized low-density lipoprotein (Ox-LDL), which has been implicated in the pathogenesis of atherosclerosis. We investigated the G501C mutation in the OLR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 274 age- and sex-matched healthy controls using single nucleotide primer extension analysis (SNuPe). There was no significant difference in the polymorphism between patients with ischemic CVD and controls (GC + CC versus GG, p = 0.48). The C allele was not significantly different between the patients and controls (C versus G, p = 0.91). Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population.
AB - The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is the major endothelial scavenger receptor against oxidized low-density lipoprotein (Ox-LDL), which has been implicated in the pathogenesis of atherosclerosis. We investigated the G501C mutation in the OLR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 274 age- and sex-matched healthy controls using single nucleotide primer extension analysis (SNuPe). There was no significant difference in the polymorphism between patients with ischemic CVD and controls (GC + CC versus GG, p = 0.48). The C allele was not significantly different between the patients and controls (C versus G, p = 0.91). Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population.
KW - Atherosclerosis
KW - Ischemic stroke
KW - Oxidized LDL
KW - Oxidized low-density lipoprotein receptor 1
KW - Polymorphism
KW - Single nucleotide primer extension
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U2 - 10.1016/j.brainres.2006.08.091
DO - 10.1016/j.brainres.2006.08.091
M3 - Article
C2 - 17022953
AN - SCOPUS:33750706221
VL - 1121
SP - 246
EP - 249
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 1
ER -