G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke

Hidenori Hattori, Akira Sonoda, Hideki Sato, Daisuke Ito, Norio Tanahashi, Mitsuru Murata, Ikuo Saito, Kiyoaki Watanabe, Norihiro Suzuki

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is the major endothelial scavenger receptor against oxidized low-density lipoprotein (Ox-LDL), which has been implicated in the pathogenesis of atherosclerosis. We investigated the G501C mutation in the OLR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 274 age- and sex-matched healthy controls using single nucleotide primer extension analysis (SNuPe). There was no significant difference in the polymorphism between patients with ischemic CVD and controls (GC + CC versus GG, p = 0.48). The C allele was not significantly different between the patients and controls (C versus G, p = 0.91). Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population.

Original languageEnglish
Pages (from-to)246-249
Number of pages4
JournalBrain Research
Volume1121
Issue number1
DOIs
Publication statusPublished - 2006 Nov 22

Fingerprint

Oxidized LDL Receptors
Cerebrovascular Disorders
Stroke
Genes
Scavenger Receptors
Atherosclerosis
Nucleotides
Alleles
Mutation
Population

Keywords

  • Atherosclerosis
  • Ischemic stroke
  • Oxidized LDL
  • Oxidized low-density lipoprotein receptor 1
  • Polymorphism
  • Single nucleotide primer extension

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke. / Hattori, Hidenori; Sonoda, Akira; Sato, Hideki; Ito, Daisuke; Tanahashi, Norio; Murata, Mitsuru; Saito, Ikuo; Watanabe, Kiyoaki; Suzuki, Norihiro.

In: Brain Research, Vol. 1121, No. 1, 22.11.2006, p. 246-249.

Research output: Contribution to journalArticle

Hattori, H, Sonoda, A, Sato, H, Ito, D, Tanahashi, N, Murata, M, Saito, I, Watanabe, K & Suzuki, N 2006, 'G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke', Brain Research, vol. 1121, no. 1, pp. 246-249. https://doi.org/10.1016/j.brainres.2006.08.091
Hattori, Hidenori ; Sonoda, Akira ; Sato, Hideki ; Ito, Daisuke ; Tanahashi, Norio ; Murata, Mitsuru ; Saito, Ikuo ; Watanabe, Kiyoaki ; Suzuki, Norihiro. / G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke. In: Brain Research. 2006 ; Vol. 1121, No. 1. pp. 246-249.
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AU - Saito, Ikuo

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