Yamanaka et al. demonstrate that GABA triggers mitochondrial Mg 2+ release in neurons at specifically developmental early stages, and the physiological Mg 2+ redistribution into cytoplasm regulates ERK, CREB, and mTOR activities with target-dependent manners, thereby facilitating neuronal maturation. Mg 2+ is a novel signal transducer.
- cellular information processing
- magnesium ion
- neuronal development
- signal transduction
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)